brinzolamide


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brinzolamide

 [brin-zo´lah-mīd]
a carbonic anhydrase inhibitor used in treatment of open-angle glaucoma and ocular hypertension.

brinzolamide

/brin·zo·la·mide/ (brin-zo´lah-mīd) a carbonic anhydrase inhibitor used in the treatment of open-angle glaucoma and ocular hypertension.

brinzolamide

[brin-zo′lah-mīd]
a carbonic anhydrase inhibitor used in treatment of open-angle glaucoma and ocular hypertension.

Azopt

A topical carbonic anhydride inhibitor that reduces intraocular pressure, used in patients with ocular hypertension or open-angle glaucoma.
 
Adverse effects
Blurred vision and bitter, sour or unusual taste (5–10% of patients); less commonly, blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus, rhinitis.

Azopt®

A topical carbonic anhydride inhibitor that decreases intraocular pressure, used in patients with ocular hypertension or open-angle glaucoma.
 
Adverse effects
Blurred vision and bitter, sour or unusual taste (5–10% of patients); less commonly, blepharitis, dermatitis, dry eye, foreign body sensation, headache, hyperemia, ocular discharge, ocular discomfort, ocular keratitis, ocular pain, ocular pruritus or rhinitis.

brinzolamide

A carbonic anhydrase inhibitor drug used in the form of eye drops to control GLAUCOMA. A brand name is Azopt.

carbonic anhydrase inhibitors 

Drugs which inhibit the carbonic anhydrase enzyme in the ciliary epithelium of the ciliary body. This enzyme is essential for the formation of aqueous humour; its reduction results in a decrease in intraocular pressure. Those in use are sulfonamide derivatives. They are administered systemically (e.g. acetazolamide) or topically in the treatment of glaucoma. Examples: acetazolamide, brinzolamide, dichlorphenamide, dorzolamide.
References in periodicals archive ?
5% Eye drops, bott of 5 ml, Brinzolamide 1% eye drops, bott of 10 ml, Bromfenac 0.
rashes Brinzolamide Azopt Bitter metallic 10 mg/mL, 5mL BC, DE taste, burning, dry eyes.
005% and as one drop, twice daily (8:00 AM and 8:00 PM) for dorzolamide hydrochloride 2%, brinzolamide 1%, and brimonidine tartrate 0.
Yu, Development of Inclusion Complex of Brinzolamide with hydroxypropyl-b- cyclodextrin, Carbohyd.
2,4,6) Mechanism Drug Class Preparations of Action Reduction Adrenergic Brimonidine of Aqueous agonists Apraclonidine Inflow [beta]-blockers Non-selective Timolol Levobunolol Carteolol Selective [beta]-blockers Betaxolol Carbonic Systemic anhydrase Acetazolamide inhibitors Methazolamide Dichlorphenamide Topical Dorzolamide Brinzolamide Increase Cholinergics Pilocarpine in Aqueous Increase Carbachol Outflow trabecular outflow Prostaglandins Latanoprost (xalatan) and other lipid Travoprost (travatan) receptor agonists Increase Bimatoprost (lumigan) uveoscleral Unoprostone outflow Table 2: The Demographic Data of the Patients of POAG Selected for the Study Bimatoprost Timolol Maleate No.
Carbonic anhydrase inhibitors include brinzolamide (Azopt), which has no human eye data, and dorzolamide (Trusopt), which has growth restriction in one case treated with fixed combination of dorzolamide and timolol.
Three-month randomized trial of fixed-combination brinzolamide, 1%, and brimonidine, 0.
Brinzolamide (Azopt) and dorzolamide (Trusopt) are used for glaucoma and ocular hypertension.
Drug Class How it works Dipivefrin Adrenergics Reduces (Propine); intraocular pressure brimonidine (Alphagan) Apraclonidine Alpha-2 Decreases intraocular fluid (Lopidine) adrenergics production; increases drainage Betaxolol Beta blockers Decreases (Betoptic) intraocular fluid production Brinzolamide Carbonic Decreases anhydrase intraocular (Azopt) inhibitors fluid production Pilocarpine Cholinergics Increases drainage of (Isopto) intraocular fluid Dorzolomide Combination Decreases beta blocker/ intraocular (Cosopt) carbonic fluid anhydrase production inhibitor Travaprost Prostaglandin Increases analogs drainage of (Travatan) intraocular fluid