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brinzolamide

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brinzolamide /brin·zo·la·mide/ (brin-zo´lah-mīd) a carbonic anhydrase inhibitor used in the treatment of open-angle glaucoma and ocular hypertension.
brinzolamide
[brin-zo′lah-mīd]
a carbonic anhydrase inhibitor used in treatment of open-angle glaucoma and ocular hypertension.

brinzolamide [brin-zo´lah-mīd]
a carbonic anhydrase inhibitor used in treatment of open-angle glaucoma and ocular hypertension.

carbonic anhydrase inhibitors 
Drugs which inhibit the carbonic anhydrase enzyme in the ciliary epithelium of the ciliary body. This enzyme is essential for the formation of aqueous humour; its reduction results in a decrease in intraocular pressure. Those in use are sulfonamide derivatives. They are administered systemically (e.g. acetazolamide) or topically in the treatment of glaucoma. Examples: acetazolamide, brinzolamide, dichlorphenamide, dorzolamide.


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The European Medicines Agency's (EMEA) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion recommending Azarga([R] )ophthalmic solution, a fixed combination of brinzolamide and timolol, to decrease intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Alcon has submitted a new product application in the European Union for Azarga(TM) ophthalmic suspension, a fixed combination of brinzolamide and timolol.
AZARGA(TM) is a fixed combination of brinzolamide and timolol for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
 
 
 
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