brevetoxin


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bre·ve·tox·in

(brev-ĕ-tok'sin)
A structurally unique neurotoxin produced by the "red tide" dinoflagellate Ptychodiscus breve Davis (Gymnodinium breve Davis), a species of algae responsible for large fish kills and mollusk and human food poisoning in the Gulf of Mexico and along the Florida coast. Unlike previously isolated dinoflagellate toxins, such as saxitoxin, which are water-soluble sodium channel blockers, the brevetoxins are lipid-soluble sodium channel activators; used in neurobiologic research.

brevetoxin

(brev′ĕ-tok″sin) [ (Karenia) brevis + toxin]
A potent, lipid-soluble, neurotoxic compound produced by marine dinoflagellates, such as Karenia brevis, an organism initially identified in "red tides” in coastal Florida.
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References in periodicals archive ?
Key words: brevetoxin, exposure assessment, Karenia brevis, marine aerosol, particle size distribution, personal exposure, red tide.
brevis cell concentrations in seawater and brevetoxin concentrations in seawater and air) was used to confirm unexposed/exposed status.
Brevetoxin concentrations were measured by liquid chromatography mass spectrometry, high-performance liquid chromatography, and a newly developed brevetoxin enzyme-linked immunosorbent assay.
We used striped mullet as laboratory test animals to better define the uptake and elimination kinetics of brevetoxin during an aqueous exposure to the brevetoxin-producing dinoflagellate Karenia brevis.
You can examine a sample of coastal sea water almost any time and find a few red tide critters, but when the population skyrockets, the amount of brevetoxin in the water can become high enough to kill fish.
After all, brevetoxin, the naturally produced red tide poison, graces the cover of my college organic chemistry textbook.
After a 60-year overview of the history and evolution of synthesis of natural products, sections on comparative design cover classics in terpenes and alkaloid synthesis, with an additional section on miscellaneous targets such as palytoxin, brevetoxin B, and indinavir.
Bad as the neurotoxic effect might be, Baden's team unveiled at the meeting three new mechanisms of brevetoxin poisoning--detrimental changes in lung function, immunity, and DNA.
Brevetoxin, produced by the dinoflagellate Gymnodinium breve, killed approximately 150 Florida manatee, another endangered species, in 1996 (Bossart et al 1998), and was likely the cause for a smaller die-off in 1982 (O'Shea et al.
Inhibition of brevetoxin binding to the voltage-gated sodium channel by gambierol and gambieric acid-A.
Saxitoxins, brevetoxin and its derivatives, and ciguatoxin bind to different sites of voltage-dependant sodium channels, resulting in either an inhibition or a persistent activation of the channels, with consequent increase in intracellular calcium (Kao & Walkwe 1982, Gutierrez et al.
He laced the rodents' food with the drug for a week and then exposed the animals to brevetoxin, the poison made by Florida's red tide algae (SN: 11/30/02, p.