breast marker

breast marker

A popular term for an antigen variably present in breast tissue, which is used to either differentiate between benign or malignant breast lesions, or identify the breast as the origin of metastases.

breast marker

Lab medicine An antigen variably present in breast tissue used to either differentiate between benign or malignant breast lesions, or identify the breast as the origin of metastases. See BRCA, Immunoperoxidase.
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Lack of CK5 or ADH-5 (the breast marker cocktail) staining (Figure 4, E through H) and uniform ER expression are helpful clues for the diagnosis of IP with ADH/LG-DCIS.
Because of the high sensitivity and specificity of GATA3 for breast origin, GATA3 has been widely used as a breast marker in routine clinical practice.
30) This sensitivity of GCDFP-15 as a breast marker is a function of histologic subtype and is generally greatest in lobular carcinoma (particularly those with signet ring cells) as well as tumors showing apocrine features.
Comparative sensitivities and specificities of antibodies to breast markers GCDFP-15, mammaglobin A, and different clones of GATA3: a study of 338 tumors using whole sections.
68-74) By application of a breast marker cocktail (CK5, CK14, CK7, CK18, and p63), UDH exhibits a mosaic staining pattern, and ADH and DCIS show clonal proliferation of luminal epithelial cells with negative HMWCK (basal cytokeratin) staining.
b, The breast marker cocktail staining reveals the lack of basal cell labeling ([p63.
Two IHC cocktails are now commercially available: the Breast Triple Stain (Clarient Inc, Aliso Viejo, California), which is composed of p63, CK5, and CK8/18, and the ADH-5 Breast Marker Cocktail (BioCare Medical, Concord, California), which has CK7 and CK14 in addition to p63, CK5, and CK18 antibodies.
Immunohistochemistry Panel in Cribriform Lesions of the Breast Marker CS ACC p63 Positive at the periphery Positive at the periphery and and surrounding lumens in the basaloid cells SMMHC Positive at the periphery Negative and surrounding lumens Calponin Positive at the periphery Negative and surrounding lumens c-KIT Negative Positive in the tumor cells Marker Cribriform DCIS ICC p63 Positive at the Negative periphery only SMMHC Positive at the Negative periphery only Calponin Positive at the Negative periphery only c-KIT Negative Negative Abbreviations: ACC, adenoid cystic carcinoma; CS, collagenous spherulosis; DCIS, ductal carcinoma in situ; ICC, invasive cribriform carcinoma; SMMHC, smooth muscle myosin heavy chain.
The authorisation makes the company the only sector player with a portfolio of FDA-approved image analysis algorithms and digital read applications for the five key immunohistochemistry (IHC) breast markers.
The second article focuses on papillary and nonpapillary breast lesions and their differential diagnosis; the diagnostic and prognostic IHC markers for triple-negative breast cancers, such as proline glutamic acid and leucine-rich protein (PELP1), GATA-binding protein 3 (GATA3), and androgen receptor (AR); and an example with aberrant expression of breast markers in lung adenocarcinoma.