breast cancer resistance protein


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breast cancer resistance protein

A xenobiotic transporter protein encoded by ABCG2 on chromosome 4q22, belonging to the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance, and likely serves as a cellular defence mechanism in response to mitoxantrone and anthracycline (daunorubicin and doxorubicin) exposure. It is highly expressed in the placenta, but its role there is unknown.
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Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
Another protein, Breast Cancer Resistance Protein (BCRP) has also been proposed to mediate drug resistance.
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues.
The parental cell line was transfected with breast cancer resistance protein (BCRP) cDNA to produce BCRP overexpressing subline, which was maintained with 800ng/ml G418 (Efferth et al.

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