breakthrough varicella

breakthrough varicella

mild varicella occurring in a patient who was recently vaccinated.
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The incidence rate of breakthrough varicella steadily decreased over time and no increase was observed during the 14 years of follow-up.
The study found that the annual rate of breakthrough varicella significantly increased with time after vaccination.
Considering the cell culture and animal model data for VZV-MSP and the lost B-cell epitope resulting from the D150N gE mutation, this mutation should be monitored to determine whether it plays a role in more severe cases of varicella or zoster or in breakthrough varicella in previously immunized children.