breakthrough seizure


Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia.
Related to breakthrough seizure: epilepsy

breakthrough seizure

A seizure that occurs despite the use of therapeutic concentrations of a previously effective antiepileptic drug.
See also: seizure
Mentioned in ?
References in periodicals archive ?
Adjustments in the dose may be needed if breakthrough seizures occur.
Additionally, surveyed physicians' mild dissatisfaction with the accessibility of levetiracetam IR may stem from the less favorable position of the branded AED compared with its generic counterpart--neurologists treating epilepsy at times opt for brand-prescribing in an attempt to prevent breakthrough seizures that may result from switching a patient from a branded AED to a generic.
An effective intervention for controlling breakthrough seizures is a new format of a long-known drug for epilepsy.
The criteria were pediatric neurology patients who had well-controlled epilepsy with only occasional breakthrough seizures.
It is estimated that between 30% and 40% of these patients are uncontrolled on oral therapy and are at-risk for acute breakthrough seizures.
Valeant Pharmaceuticals (NYSE:VRX) today announced that it has signed an agreement with GlaxoSmithKline (NYSE:GSK) for the promotion of Diastat[R] and Diastat[R] AcuDial[TM], the first and only FDA-approved, acute at-home medication for patients two years and older on stable antiepileptic medications (AEDs) who experience bouts of increased seizure activity, sometimes called serial or cluster seizures or breakthrough seizures.
Unlike other antiepileptic drugs (AED) that require multiple doses, Trokendi XR(TM) is a novel once-daily extended-release formulation designed to improve compliance and reduce blood level fluctuations that can be associated with side effects and breakthrough seizures.