breakthrough infection


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breakthrough infection

Immunology An infection by the same organism that a vaccine is designed to protect against; BIs may be caused by exposure to the organism before the vaccine took effect, or before the entire vaccine was administered. See Booster.

breakthrough infection

An infection that occurs despite previous vaccination.
See also: infection
References in periodicals archive ?
Most patients with breakthrough infections had underlying leukemia (33/37, 89%), compared with 9/31 patients (29%) who had no breakthrough infections (p < 0.
The sequence data suggested that the detectable serotype 4 and 7 strains apparently responsible for breakthrough infection were the same as those circulating in unvaccinated military and civilian populations (16).
A sensitive and specific method for the detection of these mutants would provide an important diagnostic tool for physicians to identify various medical conditions, such as an infant breakthrough infection from a pregnant HBV carrier patient or post- transplantation relapse of liver transplant patients.
But Berkley said the positive news was somewhat tempered by a report of a single breakthrough infection in an already-infected patient who had appeared to be mounting a strong cellular immune response to HIV -- a response similar to what current generation AIDS vaccine candidates seek to mobilize in uninfected individuals.
Mallinckrodt remains extremely excited about LeuTech(TM)'s potential to become a breakthrough infection imaging agent," said Mark Thom, president of the Imaging division.