Most patients with breakthrough infections
had underlying leukemia (33/37, 89%), compared with 9/31 patients (29%) who had no breakthrough infections
(p < 0.
The sequence data suggested that the detectable serotype 4 and 7 strains apparently responsible for breakthrough infection
were the same as those circulating in unvaccinated military and civilian populations (16).
A sensitive and specific method for the detection of these mutants would provide an important diagnostic tool for physicians to identify various medical conditions, such as an infant breakthrough infection
from a pregnant HBV carrier patient or post- transplantation relapse of liver transplant patients.
But Berkley said the positive news was somewhat tempered by a report of a single breakthrough infection
in an already-infected patient who had appeared to be mounting a strong cellular immune response to HIV -- a response similar to what current generation AIDS vaccine candidates seek to mobilize in uninfected individuals.
Mallinckrodt remains extremely excited about LeuTech(TM)'s potential to become a breakthrough infection
imaging agent," said Mark Thom, president of the Imaging division.