breakthrough disease

breakthrough disease

(brāk′throo″)
Any disease that occurs in spite of adequate vaccination to prevent it, (e.g., “breakthrough varicella” or “breakthrough influenza”).
References in periodicals archive ?
The vaccine is also not completely effective; breakthrough disease occurs in vaccinated individuals.
None of the available therapies is completely effective, however, and breakthrough disease occurs in some patients on all of the approved therapies.
The ONWARD study: a Phase II placebo-controlled trial designed primarily to evaluate the safety and tolerability of adding Cladribine Tablets treatment to patients with relapsing forms of MS, who have experienced breakthrough disease while on established interferon-beta therapy.
The ONWARD (Oral Cladribine Added ON To Rebif New Formulation in Patients With Active Relapsing Disease) study: a Phase II placebo-controlled trial designed primarily to evaluate the safety and tolerability of adding cladribine tablets treatment to patients with relapsing forms of MS, who have experienced breakthrough disease while on established interferon-beta therapy.
The study, called SURPASS, is expected to enroll 1,800 patients in 27 countries and provide direct comparative data of different treatment options for RRMS patients who experience breakthrough disease activity.
The bottom line was you were very much (more) likely to get breakthrough disease the longer you were (past) getting the first vaccine," Mascola said.
Some patients on traditional lupus maintenance therapies can experience breakthrough disease activity, and our study has shown that Acthar may be an effective therapeutic alternative in such patients.
The ONWARD (Oral Cladribine added oN to interferon beta-1a in patients With Active Relapsing Disease) study: a Phase II placebo-controlled trial designed primarily to evaluate the safety and tolerability of adding Cladribine Tablets treatment to patients with relapsing forms of MS, who have experienced breakthrough disease while on established interferon-beta therapy.
Chronix Biomedical to Launch Breakthrough Disease Detection and Monitoring Service for Clinical Researchers at ASCO