BCR

(redirected from breakpoint cluster region protein)

BCR

Breakpoint cluster region. A 5.8-kb DNA segment on chromosome 22q11.23, which, in contrast to the well-studied BCR-ABL fusion protein related to malignant transformation of pluripotent haematopoietic stem cells in CML, encodes a gene product of unknown function, which has serine/threonine kinase activity and is a GTPase-activating protein for p21rac.

In CML there is a reciprocal translocation between chromosome 9q34—a site which contains the human homolog of the Abelson viral oncogene, c-abl—and chromosome 22q1, the location of the breakpoint cluster region; this translocation results in formation of the Philadelphia chromosome, which transcribes a hybrid mRNA, encoding a protein with tyrosine kinase activity.
References in periodicals archive ?
Six most up-regulated proteins in HaCaT against DNBS stimulation were chromosome X ORF 26 (Cxorf26), co-chaperone P23 (PTGES3), calmodulin (CALM3), interferon-gamma inducing factor precursor (IL-18), smooth muscle/non-muscle myosin alkali light chain (MYL6)and breakpoint cluster region protein 1 (BANF1).
Among identified proteins, the 6 most up-regulated proteins were chromosome X open reading frame 26 (Cxorf26), calmodulin (CALM3), human co-chaperone P23 (PTGES3), smooth muscle and non-muscle myosin alkali light chain (MYL6) and breakpoint cluster region protein 1 (BANF1) and IL-18, the 2most down-regulated proteins were elongin B isoform alpha (TCEB2) and ribosomal protein L23(RPL23).