bDNAsignal amplification assay

(redirected from branched DNA signal amplification)

bDNAsignal amplification assay

A molecular probe technique based on branched DNA (bDNA) for hybridisation signal amplification. One end of the bDNA binds a specific target; the other end has multiple branches of DNA that bind to a probe for signal detection.
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A branched DNA signal amplification assay for quantification of nucleic acid targets below 100 molecules/ml.
These modified branching non-nucleoside bases, which BioGenex refers to as "diverge DNA", avoids the problem of non-specific hybridization that is seen with branched DNA signal amplification and detection.
The study, conducted at the University of Pittsburgh, shows that detection of HIV RNA by branched DNA signal amplification (bDNA) more accurately predicts HIV disease outcome than other commonly used markers, including CD4+ T-cell numbers, p24 antigen levels, and neopterin and beta2-microglobulin levels.
The second technique was branched DNA signal amplification, a newly approved method of directly detecting the level of HIV in the blood.
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