brainstem glioma

brain·stem gli·o·ma

a glioma, generally an astrocytoma, arising in the medulla, pons, or midbrain.

brainstem glioma

A tumour of the pons and medulla between the aqueduct of Sylvius and the fourth ventricle, which comprises ±2.4% of all intracranial tumours in adults and 15% of pediatric brain tumours, which some authors divide into anatomic regions: tectal, cervicomedullary and diffuse intrinsic pontine, which has a poor prognosis.
 
Clinical findings
Diplopia, facial weakness, headache, nausea, vomiting, dysphagia, gait ataxia, hydrocephalus. Symptoms are linked to the space-occupying nature of these tumours. Death may be caused by increased intracranial pressure and herniation.
 
Management
Radiation therapy, chemotherapy.

Mortality
Brainstem gliomas are more indolent in adults than children.
 
Good prognosticators
Neurofibromatosis, symptoms of at least 12-month duration before diagnosis, exophytic location, low-grade histology, focal tectal and cervicomedullary tumours, CT calcification.
 
Poor prognosticators
Younger than 2, multiple brainstem signs, cranial nerve palsies, diffuse pontine lesions of the pons, short duration, high-grade histology.

brainstem glioma

Neurology A tumor of the pons and medulla which comprises ±15% of pediatric brain tumors Clinical Double vision, facial weakness, vomiting, gait ataxia Management RT, chemotherapy Mortality Up to 30%
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References in periodicals archive ?
Food and Drug Administration (FDA) has given the company permission to conduct an open-label study of Antineoplastons A10 and AS2-1 in patients > 3 months of age with a diffuse intrinsic brainstem glioma (DIPG).
Our patient was an 80-year-old man initially thought to have a brainstem glioma or lymphoma.
announced in January that it has partnered with Premier Research, a global clinical research services provider, to initiate and manage a pivotal phase III clinical trial of combination antineoplastons therapy (ANP) plus radiation therapy in children newly diagnosed with a type of brainstem tumor: diffuse intrinsic brainstem glioma (DBSG).
In the Phase I study to evaluate the safety and immune responses to ICT-107, 21 patients were enrolled, including 17 newly diagnosed (16 evaluable as one did not receive any treatment) and three recurrent GBM patients and one with brainstem glioma.
The FDA has determined that under its IND the Company may initiate its planned Phase 3 study in newly diagnosed diffuse, intrinsic, brainstem glioma.
While there, he and his team developed a mouse model for brainstem glioma.
1] was a collaborative effort to better understand brainstem glioma, a deadly form of brain cancer that strikes children and young adults.
In phase II studies, a total of eighty evaluable patients with advanced non-operable brainstem glioma (BSG) have been treated with ANP administered intravenously through an ambulatory infusion pump.
BRI) today announced that it has partnered with Premier Research, a global clinical research services provider, to initiate and manage a pivotal Phase III clinical trial of combination antineoplaston therapy (ANP) plus radiation therapy in patients with newly-diagnosed, diffuse, intrinsic brainstem glioma.
She is receiving treatment for a cancerous tumor called brainstem glioma.
Ian Pollack, 27 children were enrolled, including 16 with newly diagnosed brainstem glioma (BSG), five with newly diagnosed cerebral high grade glioma (HGG), and six with recurrent gliomas.

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