brain-derived neurotrophic factor


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brain-derived neurotrophic factor

A small nerve growth factor encoded on chromosome 11p13, which promotes the survival, migration and differentiation of neuronal precursors in the peripheral and central nervous system, and supports survival of primary sensory neurones originating from the neural crest and ectodermal placodes that do not respond to nerve growth factor (NGF). BDGF participates in axonal growth, pathfinding and in modulating dendritic growth and morphology.
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Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the dentate gyrus.
2007) Influence of endogenous and exogenous sex hormones on plasma brain-derived neurotrophic factor.
Given the involvement of brain-derived neurotrophic factor (BDNF) in synaptic plasticity, it may be useful to evaluate the potential regulation of BDNF signaling by HDAC2 in learning at the neuronal and behavioral levels.
Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging.
Ethanol exposure enhances cell death in the developing cerebral cortex: Role of brain-derived neurotrophic factor and its signaling pathways.
The effects of brain-derived neurotrophic factor and metformin on in vitro developmental competence of bovine oocytes.
Preclinical studies suggest that brain-derived neurotrophic factor is increased by antidepressant drugs, so researchers turned to another compound that increases BDNF, the dopamine receptor agonist pramipexole, which is approved to treat Parkinson's disease.
Gao reported a study in which exogenous neurotrophic factors were applied to postnatal rat cochlear explant cultures that had been exposed to different classes of ototoxins; neurotrophin-4/5, brain-derived neurotrophic factor (BDNF), and neurotrophin-3 were found to protect spiral ganglion neurons from ototoxicity induced by gentamicin, sodium salicylate, and cisplatin.
Thousand Oaks-based Amgen and partner Regeneron Pharmaceuticals disclosed that testing of BDNF, or brain-derived neurotrophic factor, showed there was no improvement in the breathing capacity in a Phase III, or late-stage, trial of about 1,000 patients with amyotrophic lateral sclerosis or ALS, also known as Lou Gehrig's disease in memory of the baseball star who died of it in 1941.
Hsiun-Ing Chen from Department of Physiology of College of Medicine, National Cheng Kung University (NCKU), Taiwan, published the research paper, entitled "Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I," in the Journal of Physiology this May.