bradykinin


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Related to bradykinin: Prostaglandins, histamine, kallikrein, substance P

bradykinin

 [brad″e-ki´nin]
a nonapeptide kinin formed from a plasma protein, high-molecular-weight (HMW) kininogen by the action of kallikrein; it is a very powerful vasodilator that increases capillary permeability and, in addition, constricts smooth muscle and stimulates pain receptors.

bra·dy·ki·nin

(brad'ē-kī'nin),
The nonapeptide Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, produced from the decapeptide kallidin (bradykininogen) that is produced from α2-globulin by kallikrein, normally present in blood in an inactive form and similar to trypsin in action; bradykinin is one of several plasma kinins, is a potent vasodilator, and is one of the physiologic mediators of anaphylaxis released from cytotropic antibody-coated mast cells following reaction with antigen (allergen) specific for the antibody.
[brady- + G. kineō, to move]

bradykinin

/brady·ki·nin/ (-ki´nin) a nonapeptide kinin formed from HMW kininogen by the action of kallikrein; it is a very powerful vasodilator and increases capillary permeability; in addition, it constricts smooth muscle and stimulates pain receptors.

bradykinin

(brăd′ĭ-kī′nĭn, -kĭn′ĭn)
n.
A biologically active polypeptide, consisting of nine amino acids, that forms from a blood plasma globulin and mediates the inflammatory response, increases vasodilation, and causes contraction of smooth muscle.

bradykinin

[-kī′nin]
Etymology: Gk, bradys + kinein, to move
a peptide containing nine amino acid residues produced from α2-globulin by the enzyme kallikrein. Bradykinin is a potent vasodilator.

bradykinin

A vasoactive nonapeptide (RPPGFSPFR) formed by action of proteases on kininogens, which is very similar to kallidin (the same sequence, but with an additional N terminal lysine). It is a potent vasodilator, increasing the permeability of postcapillary venules and acting on endothelial cells to activate phospholipase A2; it is also spasmogenic for some smooth muscle and evokes pain.

bra·dy·ki·nin

(brad'ē-kī'nin)
The nonapeptide Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, normally present in blood in an inactive form; one of the plasma kinins, a potent vasodilator and mediator of anaphylaxis.
[brady- + G. kineō, to move]

bradykinin

A peptide that widens blood vessels (vasodilatation) and lowers blood pressure, increases capillary permeability and the secretion of saliva and mediates pain associated with inflammation. Bradykinin is inactivated by the angiotensin-converting enzyme.

bradykinin

a hormone formed from a kininogen in the blood plasma that has the effect of rapid VASODILATION in the skin.

bradykinin

powerful inflammatory mediator, potent vasodilator and mediator of anaphylaxis released by mast cells

bra·dy·ki·nin

(brad'ē-kī'nin)
One of several plasma kinins, a potent vasodilator; physiologic mediator of anaphylaxis released from cytotropic antibody-coated mast cells following reaction with antigen (allergen) specific for the antibody.
[brady- + G. kineō, to move]

bradykinin (brā´dəkī´nin),

n one of a number of plasma kinins, a potent vasodilator; physiologic mediators of an anaphylactic reaction.

bradykinin

a nonapeptide kinin formed from a plasma protein, high-molecular-weight (HMW) kininogen, by the action of kallikrein; it is a very powerful vasodilator that increases capillary permeability and, in addition, constricts smooth muscle and stimulates pain receptors.
References in periodicals archive ?
Bradykinin has been implicated in acute inflammatory processes due to its ability to induce an increase in blood vessel permeability.
Suppression of carrageenan-induced hyperalgesia, hyperthermia and edema by a bradykinin antagonist.
Pathways for bradykinin formation and inflammatory disease.
Role of endogenous bradykinin in human coronary vasomotor control.
35) Bradykinin, in contrast, results in vasodilation by increasing production of nitric oxide (probably by stimulating nitric oxide synthetase) as well as the vasodilating prostaglandins.
So, it is very likely that, HsC and HcE exert their anti-inflammatory effects by blocking bradykinin or other inflammation mediators.
Reduced C1-INH activity can lead to elevated plasma levels of bradykinin, which is thought to be responsible for HAE symptoms.
Isoflavone genistein inhibits the angiotensin-converting enzyme and alters the vascular responses to angiotensin I and bradykinin.
And because of lesser bradykinin effects, the risk is lower for angioede-ma, as ARBs have about a 10% incidence of angioedema, compared with ACE inhibitors," Dr.
Activated factor XII converts prekallikrein into kallikrein, and the latter cleaves high-molecular-weight kininogen into bradykinin, which mediates many of the biologic effects of this system.