Osteoblasts also produce osteoprotegerin (OPG), a soluble "decoy receptor" that blocks RANKL and maintains control of the bone remodeling
process (Giuliani et al.
1982) The stimulus for mechanically adaptive bone remodeling
Bisphosphonates have now been in use for more than 10 years and there is some concern that long-term use may cause excessive inhibition of bone remodeling
and increase in microcracks.
Besides locomotion, organ protection, and calcium-phosphorus homeostasis, the three classical functions of the skeleton, bone remodeling
affects energy metabolism through uncarboxylated osteocalcin, a recently discovered hormone secreted by osteoblasts.
Multiple studies have defined the weakness of the standard practice employed here, and the various assays for iPTH used to estimate bone remodeling
have numerous problems in addition to the novel biotin interference discovered in this case.
during the development of osteoporosis in paraplegia.
A study published in the Journal of Periodontology found that the majority of bone remodeling
occurred in the time between the implant placement and final prosthesis placement.
The delay makes sense among women taking bisphosphonates: bone remodeling
is necessary for both large and small fractures, and stopping a bisphosphonate post-fracture won't necessarily help, as the drug stays in the bones for many years.
These include the potentially favorable effects of black cohosh in bone remodeling
, ginkgo and omega 3 fatty acids in cognitive health and slowing the progression of Alzheimer's disease, resveratrol as an anti-inflammatory compound, and vitamin D in reducing prostate cancer risk.
December 6-7 American Society for Bone and Mineral Research Meeting on Targeting Bone Remodeling
for the Treatment of Osteoporosis, Omni Shoreham Hotel, Washington, DC.
Bisphosphonates prevent bone loss by binding to active sites of bone remodeling
, inhibiting osteoclast-mediated bone resorption and eventually causing osteoclast apoptosis.
The half-life in children and in pregnant women was reported to be longer, because of bone remodeling
(Gulson et al.