bone morphogenetic protein-4

bone morphogenetic protein-4

A protein encoded by BMP-4 on chromosome 14q22-q23, which plays a key role in endochondral bone formation, formation of teeth, limbs and bone from mesoderm and fracture repair. Reduced BMP4 expression has been linked to various bone diseases—e.g., fibrodysplasia ossificans progressiva.
References in periodicals archive ?
Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells.
Bone morphogenetic protein-4 (BMP-4) is a member of the transforming growth factor beta (TGF-beta) superfamily.
Topics include the role pituitary tropic status has in tumor development, the estrous cycle as an instigator of anterior pituitary cell renewal, bone morphogenetic Protein-4 control of pituitary pathophysiology, and an animal model of prolactinoma, estrogen-treated animals to use in studies, the question of whether dopamine agonist treatment should be life-long, pituitary differentiation and regulation and the implications in hormone research, the regulation of growth hormone sensitivity by sex steroid, gene therapy in the neuroendocrine system, expression of somatostatin receptor subtypes and treatment outcomes, and new aspects in the diagnosis and treatment of Cushing Disease.

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