bone metastasis

bone metastasis

A tumour found in bone. The clinical aphorism, a malignancy in bone in patients above age 35 is considered metastatic until proven otherwise.

Sites of origin
Breast, prostate, thyroid, kidney.
References in periodicals archive ?
Negative impact of bone metastasis on outcome in clear-cell renal cell carcinoma treated with sunitinib.
Objective: Bone metastasis is a common complication for breast cancer patients, affecting 70% of patients diagnosed at advanced stages.
LONDON, April 2, 2015 /PRNewswire/ -- Summary GlobalData's clinical trial report, "Bone Metastasis Global Clinical Trials Review, H1, 2015" provides data on the Bone Metastasis clinical trial scenario.
Exhaustive pipeline analysis reveals that coronary heart disease, Alzheimer's disease, breast cancer, and bone metastasis will drive the diagnostic radiopharmaceuticals market, whereas lymphoma, prostate cancer, bone metastasis, and hepatocellular carcinoma will boost the future of therapeutic radiopharmaceuticals.
Recent publications using modern imaging technologies have clearly pinpointed that BS grossly underestimates the true prevalence of bone metastasis.
Their findings suggest that microRNAs could be effective treatment targets for tackling bone metastasis aACAo and also may help doctors detect the cancer's spread to the bone, Kang said.
Contributed by surgeons, oncologists, and other medical specialists from the US, Australia, and the UK, chapters detail the clinical management of common metastases; metastasis biology, including in vitro investigations, in vivo modeling, genes that mediate metastasis organotropism, cancer invasion and metastasis from molecular and cellular perspectives, sympathetic nervous system regulation of metastasis, the role of long non-coding RNA in breast cancer metastasis, hematopoietic stem cells and bone metastasis, and microRNAs and the progression of colorectal cancer; and translational research in breast cancer metastases in bone, brain metastasis, surgical stress response and metastasis, and tumor-initiating cells and therapeutic implications.
XGEVA is also being investigated for the potential use to delay the onset of bone metastasis in adjuvant breast cancer.
In these studies, a multidisciplinary approach was applied to analyse the molecular basis of breast cancer bone metastasis, combining tools to analyse genomic information with animal models and clinical analysis of cancer metastasis.
Sagopilone inhibits breast cancer bone metastasis and bone destruction due to simultaneous inhibition of both tumor growth and bone resorption Strube A, Hoffmann J, Stepina E et al.
In this way, the drug cuts the rate of bone resorption, and may interfere with bone metastasis.