bone metastases

bone metastases

Cancer that has spread from a primary tumour to the bone marrow; in descending order of frequency, bone mets originate from: breast, prostate, lung, colon, stomach, bladder, uterus, rectum, thyroid, kidney.

Clinical findings
Bone pain, soft-tissue swelling or a pathologic fracture after minor or no reportable trauma. Chronic and severe pain, spinal epidural compression leading to spinal cord compression and bone marrow failure are complications of bone metastases that can drastically reduce the patient's quality of life and life expectancy.
 
DiffDx
• Osteolytic metastases—Osteoarthritis (subchondral cysts, Schmorl nodes), metabolic bone disease, cystic angiomatosis and infiltrative bone marrow lesions.
• Sclerotic metastases—Bone islands, tuberous sclerosis, mastocytosis or osteopoikilosis.

bone metastases

Oncology Cancer that has spread from a primary tumor to the bone
References in periodicals archive ?
The ITM Group announced today that its subsidiary ITG GmbH has successfully in-licensed DOTA-Zoledronate, a next generation theranostic agent for Bone Targeted Radionuclide Therapy and Diagnostics in patients suffering from bone metastases.
This represents the first and the fourth causes of bone metastases at post-mortem examination, with an incidence rate of 70% and 35% of cases, respectively.
Prostate cancer cells have an exquisite tropism for bone, which clinically translates into the highest rate of bone metastases amongst male cancers.
Bayer HealthCare announced today that the European Commission (EC) has granted marketing authorisation for Xofigo 1000 kBq/ml, solution for injection (radium Ra 223 dichloride) for the treatment of adults with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastases.
In patients with DTC complicated with bone metastases, treatment modalities should include total thyroidectomy, metastasectomy -if possible-, RAI therapy, and external radiation therapy (8).
Algeta ASA has announced that the US Food and Drug Administration (FDA) has approved Xofigo (radium-223 dichloride) injection for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.
Release date- 17082012 - The National Institute for Health and Clinical Excellence (NICE) has today published final draft guidance recommending denosumab (XGEVA, Amgen) as a treatment for people with bone metastases from most solid cancer tumours.
8, 2012 to discuss the supplemental Biologics License Application (sBLA) for XGEVA[R] (denosumab) to treat men with castration-resistant prostate cancer (CRPC) at high risk of developing bone metastases.
Washington, Sept 26 (ANI): A new study has found that a bone-strengthening drug could relief pain in prostate cancer patients, who develop bone metastases.
Bone scintigraphy is well established as an imaging modality for detecting bone metastases.
Commonly, thyroid carcinoma presents as a neck lump (which may be clinically solitary or multinodular) and initial presentation in the form of bone metastases leading to the diagnoses of thyroid carcinoma is rare.
2) More recent studies show that survival drops to 13-21% when bone metastases are present.