bone marrow suppression


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suppression

 [sŭ-presh´un]
the act of holding back or checking.
1. the stopping or inhibition of something, such as a secretion, excretion, normal discharge, or other function.
2. in psychiatry, conscious inhibition of an unacceptable impulse or idea as contrasted with repression, which is unconscious.
3. in genetics, a second mutation occurring at a site different from the first mutation site and able to mask or suppress the phenotypic expression of the first mutation; the organism appears to be reverted but is in fact doubly mutant.
4. inhibition of the erythrocytic stage of Plasmodium to prevent clinical attacks of malaria; used for prophylaxis.
5. cortical inhibition of perception of objects in all or part of the visual field of one eye during binocular vision.
bone marrow suppression reduction of the cell-forming functions of bone marrow, such as by a drug or because of replacement of the marrow by a disease process. Called also myelophthisis and myelosuppression.
labor suppression in the nursing interventions classification, a nursing intervention defined as controlling uterine contractions prior to 37 weeks of gestation to prevent preterm birth. See also labor.
lactation suppression in the nursing interventions classification, a nursing intervention defined as facilitating the cessation of lactation and minimizing breast engorgement after childbirth.
overdrive suppression the suppression of intrinsic cellular automaticity by a rapid outside stimulus. In cardiology this refers to the inhibitory effect of a faster pacemaker on a slower pacemaker. The faster rate causes an accumulation of intracellular sodium, stimulating the sodium-potassium pump, which hyperpolarizes the cell so that it takes longer to reach threshold potential. This phenomenon is present in healthy His-Purkinje cells but decreases with a decrease in membrane potential and loss of fast sodium channels.

bone marrow suppression

suppression of bone marrow activity, resulting in reduction in the number of platelets, red cells, and white cells, such as in aplastic anemia. Also called myelosuppression.

bone marrow suppression

Oncology A reduction of BM stem cells, a side effect of chemotherapeutics and antivirals–eg, AZT; BMS leads to ↓ WBCs, RBCs and platelets, ergo, anemia, bacterial infections and spontaneous or excess bleeding

Bone marrow suppression

A decrease in cells responsible for providing immunity, carrying oxygen, and those responsible for normal blood clotting.

bone marrow

the soft, organic material in the cavities of bones, a network of blood vessels and special connective tissue fibers that hold together a composite of fat and blood-producing cells.
The chief function of bone marrow is to manufacture erythrocytes, leukocytes and platelets. These blood cells normally do not enter the bloodstream until they are fully developed, so that the bone marrow contains cells in all stages of development. If the body's demand for white cells is increased because of infection, the bone marrow responds immediately by increasing production. The same is true if more red blood cells are needed, as in hemorrhage or anemia.
There are two types of bone marrow, red and yellow. The former produces the blood cells; the latter, which is mainly formed of fatty tissue, normally has no blood cell-producing function.

bone marrow aplasia
any of the three cell lines may be singularly aplastic but a pancytopenic abnormality is most common. See also aplastic anemia.
bone marrow aspiration
see bone marrow biopsy.
congenital bone marrow hypoplasia
bone marrow-derived cells
see B lymphocyte.
bone marrow displacement
bone marrow dyscrasia
abnormal cell production by the bone marrow. Occurs in some dog breeds, especially Poodles, in which there are maturation abnormalities of erythrocytes with macrocytosis and hypersegmented neutrophils.
bone marrow spaces
the cavities in cancellous bone that are usually filled with bone marrow.
bone marrow suppression
some drugs and infectious agents can cause reduced erythropoiesis, myelopoiesis and megakaryocytopoiesis. See also anemia, pancytopenia.
toxic bone marrow arrest
see resurgence granulopoiesis.
bone marrow transplantation
the transfer of bone marrow from a normal, antigenically matched individual to another, usually for treatment of aplastic anemia, immunodeficiency or metabolic disorders.
References in periodicals archive ?
These can include fatigue, headache, seizures, chemotherapy-induced nausea, vomiting, and bone marrow suppression.
Although CBC values were normal after RAI treatment, the statistical results showed that RAI doses were important for bone marrow suppression.
Blood monitoring for bone marrow suppression is important for people on azathioprine.
Over 600 patients to date have received romidepsin in clinical trials with the most common adverse effects including fatigue, gastrointestinal disturbances and generally mild to moderate bone marrow suppression.
Oral indibulin, by contrast, has been very well tolerated, with none of the neurotoxicity or bone marrow suppression seen with taxanes and vinca alkaloids.
The most common toxicities were mild to moderate and gastrointestinal or renal related, with no reports of central nervous system or bladder toxicities and no significant bone marrow suppression or alopecia.
Presentation of positive phase II ZIO-201 interim sarcoma data at the European Society for Medical Oncology (ESMO), which demonstrated clinical benefit and showed ZIO-201 to be well tolerated at the phase II dose with no significant bone marrow suppression, alopecia (hair loss) or neurotoxicity reported;
ZIO-201 is well tolerated with adverse events primarily mild to moderate and gastrointestinal or renal related, while no significant bone marrow suppression, alopecia (hair loss), or neurotoxicity were reported.
ZIO-201 was shown to be well tolerated at the phase II dose with no significant bone marrow suppression, alopecia (hair loss) or neurotoxicity reported.
Darinaparsin has been well tolerated and no clinically relevant QT prolongation, bone marrow suppression or neuropathy has been observed with either treatment schedule.

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