bone marrow failure

Also found in: Dictionary, Thesaurus, Legal, Encyclopedia.
Related to bone marrow failure: aplastic anemia


inability to perform or to function properly.
adult failure to thrive a nursing diagnosis accepted by the North American Nursing Diagnosis Association, defined as a progressive functional deterioration of a physical and cognitive nature. The individual's ability to live with multisystem diseases, cope with ensuing problems, and manage his/her care are remarkably diminished.
bone marrow failure failure of the hematopoietic function of the bone marrow; see also bone marrow suppression.
congestive heart failure see congestive heart failure.
heart failure see heart failure.
kidney failure renal failure.
multiple organ failure failure of two or more organ systems in a critically ill patient; see also multiple organ failure.
renal failure see renal failure.
respiratory failure see respiratory failure.
failure to thrive (failure to thrive syndrome) physical and developmental retardation in infants and small children. The syndrome can be seen in children with a physical illness, but the term is most often taken to mean failure to thrive due to psychosocial effects such as maternal deprivation. The syndrome was first noticed when European psychiatrists studied the development of babies who had spent the first five years of their lives in institutions where they were deprived of the emotional warmth of a mother, father, or other primary caregiver.

Characteristics of the failure to thrive syndrome include lack of physical growth (for example, weight and height below the third percentile for age) and below normal achievement in fine and gross motor, social-adaptive, and language skills as assessed by psychometric testing using a tool such as the Denver Developmental Screening Test. Additionally, the child with this syndrome displays withdrawing behavior, avoidance of eye contact, and stiffness or flaccid posture when held. These children often have a history of irritability, feeding problems, and disturbed sleep patterns.

Parents of infants with failure to thrive syndrome typically display feelings of concern and inadequacy. The infant who is feeding poorly and is irritable may elicit a response in the caregiver that reflects tension and frustration. The need for comfort and nurturing by the infant may not be met, and this may lead to a cycle that exacerbates feeding problems.

Intervention encompasses identification of infants and mothers at risk for the syndrome and care of both mother or primary caregiver and infant. The major goals are to encourage the mother to express her feelings without fear of rejection, to model the role of mother and teach her nurturing behaviors, and to promote her self-esteem and confidence. Important nursing goals in the care of the infant include providing optimal nutrition, comfort, and rest; meeting the infant's psychosocial needs; and supplying emotional nurturance and sensory stimulation appropriate to the assessed developmental level.
ventilatory failure respiratory failure.

bone marrow failure

failure of the hematopoietic function of the bone marrow. See also hematopoietic system.

bone marrow failure

A term of art referring to the inability of the bone marrow to maintain production of one or more stem cell lines—erythrocytes, granulocytes or megakaryocytes—at the level required for adequate function.

Bone marrow failure
Erythroid failure
Anaemia—Pure red cell aplasia, sideroblastic anaemia, congenital dyserythropoietic anaemia, haemolytic anaemia, paroxysmal nocturnal haemoglobinuria, anaemia of chronic disease/anaemia of chronic inflammation, megaloblastic anaemia.

Granulocytic failure
Neutropenia—Schwachman-DIamond syndrome, severe congenital neutropenia, Kostmann syndrome, cyclic neutropenia, immune-related neutropenia, non-immune neutropenia.

Megakaryocytic failure
Thrombocytopenia—Congenital amegakaryotic thrombocytopenia, thrombocytopenia with absent radii, immune-related thrombocytopenia, non-immune thrombocytopenia.

Total marrow failure
Pancytopenia—Fanconi anaemia, dyskeratosis congenita, aplastic anaemia, myelodysplastic syndromes.
References in periodicals archive ?
Mutations of telomerase complex genes linked to bone marrow failures.
The study findings provide, for the first time, a detailed molecular connection between chronic inflammation, and bone marrow failure and diseases of the blood.
Anaemia associated with bone marrow failures is a serious and potentially fatal disorder unless intervened by appropriate treatment.
Unaffected individuals--particularly family members of affected individuals--or individuals with other causes of bone marrow failure may also demonstrate telomere shortening.
Though Alise is still battling her condition, the bone marrow transplant will protect her from bone marrow failure and from the chance of an onset of leukemia that often accompanies Fanconi anemia.
Specific disorders eligible for HPC-C treatment include patients with hematologic malignancies, primary immunodeficiency diseases, bone marrow failure, and beta-thalassemia.
She is diagnosed with Fanconi Anaemia, a rare genetic disorder that can cause bone marrow failure.
EMMERDALE (ITV1) After weeks of worrying, Debbie and Andy finally learn what's wrong with Sarah as she is diagnosed with Fanconi Anaemia, a rare genetic disorder that can cause bone marrow failure and predisposition to cancer.
If untreated, these diseases can lead to fatal bone marrow failure and loss of organ function throughout a dog's body.
The most popular hypothesis is that EMH is a response to bone marrow failure.
People who receive a lethal dose of radiation as in the setting of an accidental exposure die of bone marrow failure.
Clopidogrel may be found to be associated with severe bone marrow suppression manifested as bone marrow failure (2), aplastic anemia, thrombocytopenia, neutropenia.

Full browser ?