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bone marrow failure

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failure /fail·ure/ (fāl´yer) inability to perform or to function properly.
acute congestive heart failure  rapidly occurring cardiac output deficiency marked by venocapillary congestion, hypertension, and edema.
backward heart failure  a concept of heart failure emphasizing the causative contribution of passive engorgement of the systemic venous system, as a result of dysfunction in a ventricle and subsequent pressure increase behind it.
bone marrow failure  failure of the hematopoietic function of the bone marrow.
congestive heart failure  (CHF) that characterized by breathlessness and abnormal sodium and water retention, resulting in edema, with congestion of the lungs or peripheral circulation, or both.
diastolic heart failure  heart failure due to a defect in ventricular filling caused by an abnormality in diastolic function.
forward heart failure  a concept of heart failure that emphasizes the inadequacy of cardiac output relative to body needs and considers venous distention as secondary.
heart failure  inability of the heart to pump blood at a rate adequate to fill tissue metabolic requirements or the ability to do so only at an elevated filling pressure; defined clinically as a syndrome of ventricular dysfunction with reduced exercise capacity and other characteristic hemodynamic, renal, neural, and hormonal responses.
high-output heart failure  that in which cardiac output remains high; associated with hyperthyroidism, anemia, arteriovenous fistulas, beriberi, osteitis deformans, or sepsis.
kidney failure  renal f.
left-sided heart failure , left ventricular failure failure of adequate output by the left ventricle, marked by pulmonary congestion and edema.
low-output heart failure  that in which cardiac output is decreased, as in most forms of heart disease, leading to manifestations of impaired peripheral circulation and vasoconstriction.
premature ovarian failure  premature menopause.
renal failure  inability of the kidney to excrete metabolites at normal plasma levels under normal loading, or inability to retain electrolytes when intake is normal; in the acute form, marked by uremia and usually by oliguria, with hyperkalemia and pulmonary edema.
right-sided heart failure , right ventricular failure failure of adequate output by the right ventricle, marked by venous engorgement, hepatic enlargement, and pitting edema.
systolic heart failure  heart failure due to a defect in the expulsion of blood that is caused by an abnormality in systolic function.
failure to thrive  physical and developmental retardation in infants and small children, sometimes from physical illness and sometimes from psychosocial effects such as maternal deprivation.

bone marrow failure,
failure of the hematopoietic function of the bone marrow. See also hematopoietic system.

failure [fāl´yer]
inability to perform or to function properly.
adult failure to thrive a nursing diagnosis accepted by the North American Nursing Diagnosis Association, defined as a progressive functional deterioration of a physical and cognitive nature. The individual's ability to live with multisystem diseases, cope with ensuing problems, and manage his/her care are remarkably diminished.
bone marrow failure failure of the hematopoietic function of the bone marrow; see also bone marrow suppression.
congestive heart failure see congestive heart failure.
heart failure see heart failure.
kidney failure renal failure.
multiple organ failure failure of two or more organ systems in a critically ill patient; see also multiple organ failure.
renal failure see renal failure.
respiratory failure see respiratory failure.
failure to thrive (failure to thrive syndrome) physical and developmental retardation in infants and small children. The syndrome can be seen in children with a physical illness, but the term is most often taken to mean failure to thrive due to psychosocial effects such as maternal deprivation. The syndrome was first noticed when European psychiatrists studied the development of babies who had spent the first five years of their lives in institutions where they were deprived of the emotional warmth of a mother, father, or other primary caregiver.

Characteristics of the failure to thrive syndrome include lack of physical growth (for example, weight and height below the third percentile for age) and below normal achievement in fine and gross motor, social-adaptive, and language skills as assessed by psychometric testing using a tool such as the Denver Developmental Screening Test. Additionally, the child with this syndrome displays withdrawing behavior, avoidance of eye contact, and stiffness or flaccid posture when held. These children often have a history of irritability, feeding problems, and disturbed sleep patterns.

Parents of infants with failure to thrive syndrome typically display feelings of concern and inadequacy. The infant who is feeding poorly and is irritable may elicit a response in the caregiver that reflects tension and frustration. The need for comfort and nurturing by the infant may not be met, and this may lead to a cycle that exacerbates feeding problems.

Intervention encompasses identification of infants and mothers at risk for the syndrome and care of both mother or primary caregiver and infant. The major goals are to encourage the mother to express her feelings without fear of rejection, to model the role of mother and teach her nurturing behaviors, and to promote her self-esteem and confidence. Important nursing goals in the care of the infant include providing optimal nutrition, comfort, and rest; meeting the infant's psychosocial needs; and supplying emotional nurturance and sensory stimulation appropriate to the assessed developmental level.
ventilatory failure respiratory failure.


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For instance, in theory embryonic stem cells could be tweaked in a lab to provide a patient with bone marrow failure a fresh supply of compatible HSCs.
Most of these patients had preexisting hematologic disorders that are frequently associated with bone marrow failure.
 
 
 
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