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blood-brain barrier (BBB)

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blood-brain barrier (BBB)
the barrier separating the blood from the brain parenchyma everywhere except in the hypothalamus. It is permeable to water, oxygen, carbon dioxide and nonionic solutes, such as glucose, alcohol and general anesthetics, and is only slightly permeable to electrolytes and other ionic substances. Some small molecules, e.g. amino acids, are taken up across the barrier by specific transport mechanisms.
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Blood-Brain Barrier (BBB) research embodies the true meaning of a "translational model" of neuroscience wherein breakthroughs in basic neuroscience are delivered to the clinic and require an agent delivery strategy and/or the ability to target specific areas of the brain.
Neuroprotective CNS barriers in neurological diseases by Environmental Health Perspectives
Long recognized as "the A in ADME", pION has commercialized PAMPA and developed applications that are highly correlated with Caco-2, gastrointestinal tract (GIT) and blood-brain barrier (BBB) permeation.
Tecan and pION Team up to Cost Effectively Screen Drug Permeability by Business Wire
Two accessory mechanisms are also suggested to be involved in MCS, one involving nitric oxide and the other peroxynitrite:nitric oxide inhibition of cytochrome P450 activity and peroxynitrite-mediated increased permeability of the blood-brain barrier (BBB) (Pall 2002b; Pall and Satterlee 2001).
Elevated nitric oxide/peroxynitrite theory of multiple chemical ... by Pall, Martin L. / Environmental Health Perspectives
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