blood substitute


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blood sub·sti·tute

any material (for example, human plasma, serum albumin, or a solution of such substances as dextran) used for transfusion in hemorrhage and shock.

blood substitute

a substance used for a replacement or volume expansion for circulating blood. Plasma, human serum albumin, packed red cells, platelets, leukocytes, and concentrates of clotting factors are often administered in place of whole blood transfusions in the treatment of various disorders. Substances that are sometimes used to expand blood volume include dextran, hetastarch, albumin solutions, or plasma protein fraction. Perfluorocarbon emulsions, although potentially toxic, have been tested as blood substitutes; they are able to carry oxygen to tissues, have a long shelf life without refrigeration, and do not induce antigen-antibody reactions.

blood sub·sti·tute

(blŭd sŭbsti-tūt)
Material (e.g., human plasma, serum albumin, a solution of substances such as dextran) used for transfusion in hemorrhage and shock.

blood substitute

Any fluid substance used for transfusion that can perform one or more of the functions of blood. Blood substitutes include PLASMA solutions, dextran solutions and saline and other electrolyte solutions. Genuine blood substitutes that can transport oxygen are still in the experimental stages.
References in periodicals archive ?
Scientists have thus been forced to look for alternatives for donated blood, which are called artificial blood substitutes, artificial haemoglobin or haemoglobin based oxygen carriers (HBOC).
The effect of blood substitute on the Hitachi 917 measurement point data was examined in closer detail using a serum specimen with an alkaline phosphatase activity of 500 U/L.
Alliance Pharmaceutical in San Diego has created a blood substitute made of synthetic chemicals called perfluorocarbons.
Chang and his numerous colleagues and contributors have been successful in condensing and centralizing basic information as well as the current developments in the area of blood substitutes in a user-friendly and manageable manner, which is quite a feat considering the highly interdisciplinary nature of the field of blood substitutes.
The use of Adenosine and GSH to modify hemoglobin was presented as a viable strategy for a new generation blood substitute.
The company plans to pasteurize the hemoglobin, a process that reduces the risk that a blood substitute will harbor disease-causing microbes.
This strategy was cited by the FDA as a strategy for a new generation hemoglobin based blood substitute at an FDA meeting on April 29, 2008.
Several researchers, including Enrico Bucci of the University of Maryland School of Medicine in Baltimore, have developed ways of cross-linking human hemoglobin molecules into cell-free blood substitutes (SN: 9/26/87, p.
HemoTech represents a second-generation blood substitute that uses novel pharmacological cross-linking technology (with adenosine and reduced glutathione), developed by Texas Tech scientists, to prevent the toxic reactions of hemoglobin that have appeared in the first generation products mentioned in the JAMA article above.
com), a biopharmaceutical company focused on developing and commercializing the first viable human blood substitute, will present at the EQUITIES 57th Anniversary Spring Conference to be held at the Princeton Club on April 18th, in New York City.
One advantage of freeze-drying for the medics -who sould have to carry the blood substitute into the field - is that the removal of water reduces weight and increases compressibility, according to Alan Rudolph, Barbara Rudolph's husband and a chemist at the Naval Research Laboratory.
CEO Discusses HemoTech, Potentially the First Viable Human Blood Substitute