bleomycin


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Related to bleomycin: cisplatin, doxorubicin

bleomycin

 [ble″o-mi´sin]
an antitumor antibiotic obtained from cultures of Streptomyces verticellus. It binds to DNA and causes single-strand breaks and double-strand scissions, impairing DNA synthesis and inhibiting RNA and protein synthesis. Administered by injection as the sulfate salt to treat lymphomas, soft tissue sarcomas, and cancers of the head and neck, cervix, skin, testes, lung, and other organs.

bleomycin

/ble·o·my·cin/ (ble-o-mi´sin) a polypeptide antibiotic mixture obtained from cultures of Streptomyces verticellus; used as the sulfate salt as an antineoplastic.

bleomycin

(blē′ə-mī′sĭn)
n.
Any of a group of antibiotics obtained from the bacterium Streptomyces verticillus. A mixture of them, usually in the form of their sulfate salts, is used as an antineoplastic agent.

bleomycin

(blē′ə-mī′sĭn)
n.
Any of a class of antibiotics isolated from the bacterium Streptomyces verticillus, used usually in sulfate form in combination with other drugs to treat certain kinds of cancer.

bleomycin

A chemotherapeutic antibiotic, which consists of a mixture of low molecular weight (±1.5-kD) metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus, which is used to treat lymphomas, Hodgkin’s disease, Kaposi sarcoma, testicular cancer and other germ cell tumours.
 
Mechanism of action
Induction of single- and double-stranded breaks in DNA.
 
Adverse effects
Fever, stomatitis, skin lesions, marrow suppression, fever, chills and hair loss; fibrosis at > 200 mg/m2 total doses.

bleomycin

Blenoxane, BLEO, BLM Oncology A chemotherapeutic antibiotic, which consists of a mixture of low MW–±1.5 kD metal and oxygen-dependent DNA cleavers, isolated from Streptomyces verticillus verticellus, which is used to treat lymphomas, Hodgkin's disease, Kaposi sarcoma, testicular CA, and other germ cell tumors Mechanism of action Induction of single- and double-stranded breaks in DNA Adverse effects Fever, stomatitis, skin lesions, BM suppression, fever, chills, and hair loss

bleomycin

A toxic glycopeptide antibiotic that interferes with the synthesis of DNA and is used as an anticancer drug, usually in combination with other drugs. It has some value in HODGKIN'S DISEASE, other LYMPHOMAS and squamous cell cancers of the skin. Side effects include FIBROSIS of the lungs, drying and discoloration of the skin over the back of joints. The drug is on the WHO official list.

bleomycin

a polypeptide antibiotic mixture having antineoplastic properties, obtained from cultures of Streptomyces verticellus. Evidence indicates that bleomycin inhibits cell division, thymidine incorporation into DNA, and DNA synthesis. Has been used in dogs and cats in the treatment of squamous cell carcinoma, but side-effects, including pneumonia or pulmonary scarring, limit its use.
References in periodicals archive ?
Rosen makes tiny holes in the wart with a lancet, applies the bleomycin to a bandage, and places the bandage over the wart, so the medication enters topically rather than systemically.
The patients who were randomised ARM-B were treated with bleomycin 15 mg IV push once per week for 6 weeks concurrently with radiotherapy.
Our results confirm the rates of bleomycin lung toxicity in 15-30% of the patients treated with BEP, similar to those reported in GGCT patients (0-46%).
Severe rashes may warrant discontinuation of bleomycin.
Conclusion: Intralesional bleomycin is excellent in cystic lymphangioma, while it had good response in mixed lymphangioma.
Ionescu and colleagues4 found that patients receiving intralesional bleomycin had levels of the order of 100 times lower than cancer patients receiving it intravenously, implying lower risks of pulmonary fibrosis.
Bleomycin is associated with injection pain and rare systemic events, so it is less commonly used for wart treatment than are other methods such as cryosurgery, laser treatment, or immunotherapy.
The standard therapy arm consisted of four cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy followed by radiation therapy at 30 Gy limited to the involved field.
Bleomycin is the common antineoplastic antibiotic available in market for the treatment of epidermal neoplasm, as well as lymphoreticular and other epithelial carcinomas, including squamous cell carcinoma and malignant lymphoma (Jaroszeski et al.
The HD was staged as III BS according to the Costwolds Staging Classification, and six courses of combination chemotherapy with alternating ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) were administered.
Agents used included doxorubicin, cyclophosphamide, pad taxel, bleomycin, cisplatin, and vinblastine.
Fourteen patients were evaluated for response and safety and all had relapsed or refractory HL after initial therapy with the chemotherapy regimens ABVD (Adriamycin, bleomycin, vinblastine, dacarbazine) or BEACOPP (bleomycin, etoposide, Adriamycin, cyclophosphamide, Oncovin, procarbazine hydrochloride, prednisone) or a combination of chemotherapy with or without consolidative radiation treatment.