Patients with 8-SPD have a bleeding diathesis
of variable severity characterized by mucocutaneous bleeding and perioperative bleeding.
Family history of any disease affecting multiple members, congenital malformation, mental retardation, treatment for sub fertility/infertility, history of previous child with mental retardation, bleeding diathesis
, muscular dystrophy, transfusion dependant anaemia, other genetic diseases, significant maternal illnesses (diabetes, epilepsy, thyroid disease, heart disease, TB, fever, rashes lymphadenopathy, etc.
23) This deficiency has an autosomal recessive inheritance, usually diagnosed by a concomitant prolongation of the PT and aPTT in patients who have had a bleeding diathesis
These results, albeit from a small sub-group (n=13) would thus support the evidence of Kost in that only one patient with a bleeding diathesis
suffered a perioperative complication.
Vestibular closure with a silastic obturator--an alternative to Young's procedure in bleeding diathesis
Studies for unusual, predominantly hereditary defects, such as factor XIII deficiency, should be included in the hemostatic evaluation if routine studies are unrevealing and a bleeding diathesis
1,2) Saw palmetto has so far been implicated in hepatitis, cholecystitis, bleeding diathesis
, conduction defects, and erectile dysfunction.
These reports attribute ocular complications to the transient thrombocytopenia and resulting bleeding diathesis
INTEGRILIN is contraindicated in patients with a history of bleeding diathesis
, or evidence of abnormal bleeding within the previous 30 days; severe hypertension (systolic blood pressure greater than 200 mm Hg or diastolic blood pressure greater than 110 mm Hg) not adequately controlled on antihypertensive therapy; major surgery within the preceding six weeks; history of stroke within 30 days, or any history of hemorrhagic stroke; current or planned administration of another parenteral GP IIb-IIIa inhibitor; dependency on renal dialysis; or known hypersensitivity to any component of the product.
A lifelong bleeding diathesis
may suggest a congenital platelet dysfunction, but an onset in adulthood does not necessarily exclude a congenital problem.
Other causes are bleeding diathesis
(for example, anticoagulant use) or vasculopathies.
AGGRASTAT([R]) is contraindicated in patients with known hypersensitivity to any component of the product; active internal bleeding or a history of bleeding diathesis
within the previous 30 days; or a history of intracranial haemorrhage, intracranial neoplasm, arteriovenous malformation, or aneurysm.