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blastic transformation |
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blastic transformation, a late stage in the progress of chronic granulocytic leukemia. The leukemic cells become more undifferentiated and morphologically and genetically more abnormal, with more aggressive growth patterns. Signs of anemia and blood platelet deficiency are present, and half of the blood cells in the bone marrow are immature forms. Blastic transformation indicates that resistance to therapy has developed in the patient who has entered a terminal stage of leukemia. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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| Most cases of MS occur in patients with a history of acute myeloid leukemia (AML), but they may be the first sign of blastic transformation of a chronic myeloproliferative disorder or myelodysplastic syndrome. Chronic monocytic leukemia terminating in blastic transformation. Rapidly enlarging lymphadenopathy in a patient with an MCL can signify blastic transformation and progression to a biologically more aggressive form of lymphoma. |
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