blastic transformation

blastic transformation

a late stage in the progress of chronic granulocytic leukemia. The leukemic cells become more undifferentiated and morphologically and genetically more abnormal, with more aggressive growth patterns. Signs of anemia and blood platelet deficiency are present, and half of the blood cells in the bone marrow are immature forms. Blastic transformation indicates that resistance to therapy has developed in the patient who has entered a terminal stage of leukemia.
References in periodicals archive ?
Chronic myeloid leukemia: mechanisms of blastic transformation.
Vitamin K2 induces apoptosis of a novel cell line established from a patient with myelodysplastic syndrome in blastic transformation.
The management of chronic myeloid leukaemia (CML) has undergone a remarkable transformation in the past decade from a malignancy for which cure was available to a minority (in the form of an allogeneic bone marrow (or peripheral blood stem cell) transplant), with the rest inevitably progressing to incurable blastic transformation and death, to a disease where control with a group of remarkably well-tolerated drugs is changing both the natural history of the disease, as well as turning previous therapeutic stratagems on their collective heads.