1. Describing the formation of a conidium by the blowing out process of a fertile hypha before being limited by a septum.
2. Colloquial term for osteoblastic.
[G. blastos, germ + -ic]
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In a multicenter Phase 1/2 trial in patients with advanced acute myeloid leukemia (AML) and other hematologic malignancies including blastic plasmacytoid dendritic cell neoplasm (BPDCN), SL-401 demonstrated single agent activity, including durable complete responses (CRs), and an overall survival (OS) improvement relative to historical data in the most heavily pretreated AML patients.
The first is that the leukemic nodules arise from leukostatic plugging of small cerebral vessels during the acceleration of blastic phase (16).
In a retrospective series of 62 MCL patients, four patients developed CNS relapse at a median of 12 months (range, 1-58 months), including two patients with confirmed blastic variant (1).
The histologic features of MCC are similar to those of various other tumors, such as metastatic small cell carcinoma, the small round cell tumors, blastic hematologic malignancies of skin/soft tissue, and melanoma.
MS is made up of a diffuse, fairly monotonous infiltrate of medium-size or large cells with three levels of differentiation: blastic, immature, and diffrentiated (figure):
X-ray films showed no lytic or blastic lesions in the thigh, nor did the bone scan show any metastases.
Session Type: Poster Session 250-I Saturday, December 10, 2005, 9:15 AM Abstract Number: 1099 Phase II Study of Decitabine in Combination with Imatinib Mesylate in Patients with Accelerated (AP) or Blastic Phase (BP) of Chronic Myeloid Leukemia (CML).
a clinical-stage biopharmaceutical company developing oncology therapeutics that target both cancer stem cells (CSCs) and tumor bulk, announced today that a heavily pre-treated patient with a drug-refractory and recurrent blastic plasmacytoid dendritic cell neoplasm (BPDCN) achieved a complete response (CR) following treatment with Stemline's SL-401.
Seventeen cases (68%) were T-cell and NK/T-cell lymphomas, including 5 NKTCLs, 5 angioimmunoblastic T-cell lymphomas; 3 peripheral T-cell lymphomas, unspecified; 2 anaplastic large cell lymphomas; 1 T-cell prolymphocytic leukemia; and 1 blastic plasmacytoid dendritic cell neoplasm (blastic NK-cell lymphoma).
This pattern of MR signal characteristics would be similar for a sclerotic lesion, such as a blastic metastasis, a bone island, or possibly intravertebral gas related to avascular necrosis.
Specific chromosomal abnormalities involving band 3q21 have been observed in all FAB subtypes of acute myeloid leukemia (AML), in myelodysplastic syndrome, occasionally in the blastic phase of chronic myeloid leukemia, and rarely in chronic phase CML.