In a multicenter Phase 1/2 trial in patients with advanced acute myeloid leukemia (AML) and other hematologic malignancies including blastic
plasmacytoid dendritic cell neoplasm (BPDCN), SL-401 demonstrated single agent activity, including durable complete responses (CRs), and an overall survival (OS) improvement relative to historical data in the most heavily pretreated AML patients.
The first is that the leukemic nodules arise from leukostatic plugging of small cerebral vessels during the acceleration of blastic
In a retrospective series of 62 MCL patients, four patients developed CNS relapse at a median of 12 months (range, 1-58 months), including two patients with confirmed blastic
The histologic features of MCC are similar to those of various other tumors, such as metastatic small cell carcinoma, the small round cell tumors, blastic
hematologic malignancies of skin/soft tissue, and melanoma.
MS is made up of a diffuse, fairly monotonous infiltrate of medium-size or large cells with three levels of differentiation: blastic
, immature, and diffrentiated (figure):
X-ray films showed no lytic or blastic
lesions in the thigh, nor did the bone scan show any metastases.
Session Type: Poster Session 250-I Saturday, December 10, 2005, 9:15 AM Abstract Number: 1099 Phase II Study of Decitabine in Combination with Imatinib Mesylate in Patients with Accelerated (AP) or Blastic
Phase (BP) of Chronic Myeloid Leukemia (CML).
a clinical-stage biopharmaceutical company developing oncology therapeutics that target both cancer stem cells (CSCs) and tumor bulk, announced today that a heavily pre-treated patient with a drug-refractory and recurrent blastic
plasmacytoid dendritic cell neoplasm (BPDCN) achieved a complete response (CR) following treatment with Stemline's SL-401.
Despite progress in the treatment of early-stage CML, the accelerated and blastic
phases of CML remain a therapeutic challenge; therefore, novel treatment approaches are needed (17).
Seventeen cases (68%) were T-cell and NK/T-cell lymphomas, including 5 NKTCLs, 5 angioimmunoblastic T-cell lymphomas; 3 peripheral T-cell lymphomas, unspecified; 2 anaplastic large cell lymphomas; 1 T-cell prolymphocytic leukemia; and 1 blastic
plasmacytoid dendritic cell neoplasm (blastic
This pattern of MR signal characteristics would be similar for a sclerotic lesion, such as a blastic
metastasis, a bone island, or possibly intravertebral gas related to avascular necrosis.
Specific chromosomal abnormalities involving band 3q21 have been observed in all FAB subtypes of acute myeloid leukemia (AML), in myelodysplastic syndrome, occasionally in the blastic
phase of chronic myeloid leukemia, and rarely in chronic phase CML.