blast crisis


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Related to blast crisis: AML

crisis

 [kri´sis] (pl. cri´ses) (L.)
1. the turning point of a disease for better or worse; especially a sudden change, usually for the better, in the course of an acute disease.
2. a sudden paroxysmal intensification of symptoms in the course of a disease.
addisonian crisis (adrenal crisis) the symptoms accompanying an acute onset or worsening of addison's disease: anorexia, vomiting, abdominal pain, apathy, confusion, extreme weakness, and hypotension; if untreated these progress to shock and then death.
aplastic crisis a sickle cell crisis in which there is temporary bone marrow aplasia.
blast crisis a sudden, severe change in the course of chronic granulocytic leukemia, characterized by an increased number of blasts, i.e., myeloblasts or lymphoblasts.
catathymic crisis an isolated, nonrepetitive act of violence that develops as a result of intolerable tension.
celiac crisis an attack of severe watery diarrhea and vomiting producing dehydration and acidosis, sometimes occurring in infants with celiac disease.
developmental crisis maturational crisis.
hemolytic crisis an uncommon sickle cell crisis in which there is acute red blood cell destruction with jaundice.
hypertensive crisis dangerously high blood pressure of acute onset.
identity crisis a period in the psychosocial development of an individual, usually occurring during adolescence, manifested by a loss of the sense of the sameness and historical continuity of one's self, confusion over values, or an inability to accept the role the individual perceives as being expected by society.
life crisis a period of disorganization that occurs when a person meets an obstacle to an important life goal, such as the sudden death of a family member, a difficult family conflict, an incident of domestic violence (spouse or child abuse), a serious accident, loss of a limb, loss of a job, or rape or attempted rape.
maturational crisis a life crisis in which usual coping mechanisms are inadequate in dealing with a stress common to a particular stage in the life cycle or with stress caused by a transition from one stage to another. Called also developmental crisis.
myasthenic crisis the sudden development of dyspnea requiring respiratory support in myasthenia gravis; the crisis is usually transient, lasting several days, and accompanied by fever.
oculogyric crisis a symptom of an acute dystonic reaction in which the person demonstrates a fixed gaze, usually upward; also, the uncontrollable rolling upwards of the eye. It can be a result of encephalitis or a reaction to antipsychotic medications.
salt-losing crisis see salt-losing crisis.
sickle cell crisis see sickle cell crisis.
tabetic crisis a painful paroxysm occurring in tabes dorsalis.
thyroid crisis (thyrotoxic crisis) see thyroid crisis.
vaso-occlusive crisis a sickle cell crisis in which there is severe pain due to infarctions in the bones, joints, lungs, liver, spleen, kidney, eye, or central nervous system.

blast cri·sis

a sudden alteration in the status of a patient with leukemia in which the peripheral blood cells are almost exclusively blast cells of the type characteristic of leukemia; usually accompanied by a decrease in numbers of other formed elements of the blood, fever, and rapid clinical deterioration.
The abrupt conversion of a chronic, relatively indolent leukemia, usually CML, into an acute decompensated, accelerated phase, with a marked—30+% of WBCs—increased proportion of blasts and number of lymphocytes or myelocytes in circulation and bone marrow
Lab Leukocytosis, thrombocytosis or thrombocytopenia, anemia
Management Response to blast crises is usually short-lived; myeloblast transformations are commonly treated with hydroxyurea; one-fourth respond to prednisone with vincristine

blast crisis

Blast phase, blast transformation Oncology The abrupt conversion of a chronic, relatively indolent leukemia usually CML into an acute decompensated, accelerated phase, with a marked–30+% of WBCs—↑ proportion of blasts and number of lymphocytes or myelocytes in circulation and BM Clinical Lymphadenopathy, hepatosplenomegaly, spleen and bone pain, fever, thrombosis Lab Leukocytosis, thrombocytosis or thrombocytopenia, anemia Management Response to BCs is usually short-lived; myeloblast transformations are commonly treated with hydroxyurea;14 respond to prednisone with vincristine. Cf Blast transformation, Relapse.

Blast crisis

Stage of chronic myelogenous leukemia where large quantities of immature cells are produced by the marrow and is not responsive to treatment.
References in periodicals archive ?
Once blast crisis has been diagnosed, management depends on previous therapy and type of leukemia (myeloid or lymphoid) (13, 15).
The clinical and morphologic features at the outset did not fit a diagnosis of CML, chronic phase, accelerated phase, or blast crisis, as defined by the World Health Organization blue book (1).
Most events were mild to moderate, however the drug was discontinued for adverse events in one per cent of patients in chronic phase, two per cent in accelerated phase and five per cent in blast crisis.
Seven patients with myeloid blast crisis continue to receive treatment and remain in remission from 101 to 349 days after beginning treatment, they said.
Morphologic and immunological features of blasts in blast crisis may be discordant.
The immature appearance of the malignant cells in concert with the finding of strong immunoreactivity for CD34 and CD43 supported the diagnosis of CML in myeloid blast crisis that had not peripheralized.
The START-L (abstract 0653) enrolled 101 patients; of those, 94 patients with CML in lymphoid blast crisis (48) or Ph+ ALL (46) resistant or intolerant to imatinib received treatment.
Gleevec was approved last year for the treatment of CML patients who no longer respond to initial therapy and for patients in accelerated disease phase or blast crisis.
Previous NICE guidance issued on 12 August 2002 already stated that patients in England and Wales with Philadelphia chromosome-positive CML in the chronic phase, who are intolerant to interferon-alpha therapy, or those in the blast crisis or accelerated phase, would be provided with access to Glivec therapy.
A CML patient with an F317L BCR-ABL mutation in lymphoid blast crisis experienced a marked decrease in peripheral blast counts on XL228 (7.
In addition, Glivec is approved in over 80 countries for the treatment of adult patients with Ph+ CML in blast crisis, accelerated phase or in chronic phase after failure of interferon-alpha therapy.