blast cell


Also found in: Dictionary, Thesaurus, Legal, Financial, Encyclopedia, Wikipedia.
Related to blast cell: Auer rod, band cell, blast cell leukemia

blast cell

an immature precursor cell; for example, erythroblast, lymphoblast, neuroblast.
See also: -blast.

blast cell

n.
1. A precursor of a human blood cell.
2. An immature, undifferentiated cell.

blast cell

Etymology: Gk, blastos, germ
any immature cell, such as an erythroblast, lymphoblast, or neuroblast.

BLAST

Basic Local Alignment Search Tool. A nucleic acid- and protein-sequence comparison algorithm which is used to find matches in gene sequences and to search sequence databases for optimal local alignments to a query sequence.

BLAST uses a heuristic algorithm, seeking local alignments and creating a matrix of similarity scores for all possible pairs of residues, defining high-scoring segments, statistically evaluating the significance of the results and detecting relationships among sequences which share only isolated regions of similarity.

blast cell

Blast Hematology An immature cell in the BM's proliferative compartment, and earliest identifiable precursor of a cell line–erythroblast, lymphoblast, megakaryoblast and myeloblast; BCs are large–15-20 µm, have high N:C ratios, nuclei with fine, lacy to granular chromatin that contain one or more prominent nucleoli, basophilic, agranular cytoplasm, and abundant RNA, and actively synthesize DNA; BCs represent up to 5% of BM cells

blast cell

(blast sel)
An immature precursor cell; e.g., erythroblast, lymphoblast, neuroblast.
See also: -blast

blast cell

An immature or primitive cell from which mature, differentiated cells are derived. The term refers mainly to the progenitors of blood cells (haemopoietic cells). The presence of these in the circulating blood is a feature of acute leukaemias.
References in periodicals archive ?
The mean percentage of blast cells in the S phase in different heparin concentrations at 0, 1, and 2 h are shown in Table 4.
In addition to rapid reduction of blast cells, morphologic changes including presence of Auer rods in mature cells (Figure 1) and surface marker analysis of peripheral blood and/or bone marrow cells by flow cytometric studies confirmed the evidence of in vivo differentiation of myeloid leukemic cells.
The number of blast cells in the peripheral blood should be subtracted from the number of blasts in the CSF and the blasts in the CSF reported as two percent.
A manual diff count may not capture a few blast cells lurking on the edge of a smear, for example.
14,15) The bone marrow aspirate was positive for Sudan black, confirming the myeloid origin of the blast cells, and was positive for nonspecific esterase, which can identify early monocytic precursors and differentiate them from poorly granulated myelocytes.
The transient myeloproliferative disorder (TMD) of Down syndrome, also known as transient abnormal myelopoiesis, characteristically manifests in the first few days of life, with numerous circulating blast cells exceeding the number of blast cells in the bone marrow and spontaneous resolution within a few weeks.
Basal and modulated protein levels and the effect of modulation on protein levels in the leukemic blast cells were expressed using a variety of metrics.
Analysis of signaling pathways in residual blast cells of the patient exhibiting a CRi indicate a striking inhibition of constitutive pSTAT5, consistent with inhibition of mutant FLT3 signaling, as well as significant inhibition of stem cell factor-activated kinase S6, ERK, and Akt, all of which are consistent with c-Kit inhibition during treatment with ENMD-2076.
The building includes approximately 17,000 square feet of rack support freezer, four blast cells, 37,000 square feet of climate controlled manufacturing and warehouse areas, and approximately 10,000 square feet of racked ambient storage warehouse.
9]/L, and no evidence of leukemia in other sites); nonresponder (NR; cellular marrow with >5% blast cells or evidence of leukemia in other sites, after at least two courses of chemotherapy); and early relapse (ER; relapse within 6 months from remission) (21).