Also found in: Dictionary, Wikipedia.
Synthetic pyrophosphate analogues that inhibit osteoclast resorption of bone.
Class of medications to treat osteoporosis.
bisphosphonatesA class of drugs that resemble pyrophosphate but are not readily hydrolysed. They interfere with the action of OSTEOCLASTS and thus prevent bone reabsorption in conditions such as PAGET'S DISEASE and OSTEOPOROSIS. They have an established place in the management of metastatic bone secondaries in cancer. The class includes drugs such as clodronate and etidronate (with no nitrogen moiety attached to the central carbon atom side chain), and pamidronate, alendronate, risendronate, ibandronic acid and zoledronic acid, with the nitrogen moiety. The latter group are more potent inhibitors of bone resorption but have more side effects.
bisphosphonatestherapeutic agents (e.g. alendronic acid [Fosamax], disodium etidronate [Didronel] and risedronate [Actonel]) used to prevent and treat osteoporosis, osteogenesis imperfecta and Paget's disease
calcium-regulating drugs which inhibit bone resorption; used in the treatment of hypercalcemia and osteoporosis in humans. Previously called diphosphonates and biphosphonates.