bisphosphonates


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bis·phos·pho·nates

(bis-fos'fō-nāts),
Synthetic pyrophosphate analogues that inhibit osteoclast resorption of bone.

bis·phos·pho·nates

(bis-fos'fŏ-nāts)
Class of medications to treat osteoporosis.

bisphosphonates

A class of drugs that resemble pyrophosphate but are not readily hydrolysed. They interfere with the action of OSTEOCLASTS and thus prevent bone reabsorption in conditions such as PAGET'S DISEASE and OSTEOPOROSIS. They have an established place in the management of metastatic bone secondaries in cancer. The class includes drugs such as clodronate and etidronate (with no nitrogen moiety attached to the central carbon atom side chain), and pamidronate, alendronate, risendronate, ibandronic acid and zoledronic acid, with the nitrogen moiety. The latter group are more potent inhibitors of bone resorption but have more side effects.

bisphosphonates

therapeutic agents (e.g. alendronic acid [Fosamax], disodium etidronate [Didronel] and risedronate [Actonel]) used to prevent and treat osteoporosis, osteogenesis imperfecta and Paget's disease

bisphosphonates

calcium-regulating drugs which inhibit bone resorption; used in the treatment of hypercalcemia and osteoporosis in humans. Previously called diphosphonates and biphosphonates.
References in periodicals archive ?
Bisphosphonates are prescribed as the first choice treatment in patients with osteoporosis and they strongly inhibit bone resorption.
At the same time, findings of trials of antiresorptive agents, including bisphosphonates, in knee osteoarthritis have been conflicting.
We've been told that the risk with oral bisphosphonates is negligible, but 4% is not negligible," insisted Dr.
1) Nitrogen-containing bisphosphonates have no detrimental effect on bone growth or mineralization.
In December 2001, he was switched to risedronate, another bisphosphonate that allows for twice-weekly dosing.
Since millions of patients take oral bisphosphonates for the treatment of osteoporosis, it is timely to review what is known and needs to be learned about this emerging issue in patient careto develop a consensus on the definition of ONJ, as well as to explore potential risk factors and pathogenic mechanisms of ONJ and to explore strategies to move research forward.
In summary, our findings suggest that use of bisphosphonates is modestly associated with reduced endometrial cancer risk, a finding consistent with the inverse association between use of this medication and breast cancer risk," wrote Dr.
Bisphosphonates look pretty safe for the first few years," Dr.
Our study suggests that routine universal utilization of bisphosphonates in elderly women after distal radius fracture would not be economically advantageous despite the cost savings associated with reduction of the hip fracture burden in that population," said lead study author, Suneel B.
The endometrial cancer incidence rate among women in the study who reported ever using nitrogenous bisphosphonates was 8.
Three to five years of bisphosphonate treatment increases bone density by slowing bone resorption and reduces the rate of osteoporotic fractures, but the value of longer treatment is being questioned at the US Food and Drug Administration.
However, it cannot be used if a patient is already taking bisphosphonates or has already sustained a fragility fracture.