BIONJ

(redirected from bisphosphonate-induced osteonecrosis of the jaw)

BIONJ

Bisphosphonate-induced osteonecrosis of the jaw. A condition linked to the use of IV and oral nitrogen-containing bisphosphonate drugs, resulting in osteonecrosis of the jaw.

Drugs implicated
Zoledronate, pamidronate or combination thereof, used to treat breast cancer or myeloma. About 5% of those with BIONJ were being treated for osteoporosis.

Risk factors
Tooth extractions (50% of cases), mandibular exostoses, periodontal disease, trauma from ill-fitting dentures, smoking, obesity, use of cytotoxic drugs and glucocorticoids.
References in periodicals archive ?
Within the past year, I have seen three cases of bisphosphonate-induced osteonecrosis of the jaw.
Chicago -- Many people who currently take or who have taken bisphos-phonates are being denied essential dental procedures because of undue fears about bisphosphonate-induced osteonecrosis of the jaw, according to a specialist in oral pathology.
While the drugs have successfully helped aging patients combat bone-loss fractures and aided cancer patients with painful bone metastasis, the concern lies with the development of bisphosphonate-induced osteonecrosis of the jaw (ONJ), a deterioration of the jaw bone caused by a reduced blood supply.
Marx of the University of Miami School of Medicine (34 with bisphosphonate-induced osteonecrosis of the jaw and more than 100 patients who were on oral bisphosphonates when a surgical procedure was indicated), the following recommendations are made: