Eight patients (47%) had a history of bone marrow disease before the diagnosis of myeloid sarcoma, including 3 patients (38%) with AML, 2 patients (25%) with MDS, 2 patients (25%) with chronic myelomonocytic leukemia, and 1 patient (13%) with acute biphenotypic
T/myeloid cell leukemia.
A 4-year-old boy was referred to our hospital in February 2007 for the treatment of biphenotypic
Pathologic examination reveals a characteristic biphenotypic
cell line composed of chief cells and sustentacular cells with a peripheral fibrovascular stromal layer that are organized into a whorled (Zellballen) pattern.
Subtypes include precursor B acute lymphocytic leukemia, precursor T acute lymphocytic leukemia, Burkitt leukemia, and acute biphenotypic
In all, 763 cases 645 cases of acute lymphoblastic leukemia (ALL), 102 of acute mveloblastic leukemia (AML), and 16 of undifferentiated or biphenotypic
AL] of the 842 eligible cases consented to participate (91%).
PEL cells rarely exhibit genotypic infidelity with biphenotypic
B- and T-cell expression (positive B- and T-cell gene rearrangements) (4).
A diagnosis of granular ALL was rendered after evaluation by the EGIL (European Group on Immunologic Classification of Leukemias) biphenotypic
system showed the patient to score less than 2 points in the myeloid and T-cell groupings, which mitigates against biphenotypic
Smoothened expression was detected in lymphoid-lineage cell lines and in the biphenotypic
lymphoid/myeloid line Reh.
was diagnosed with biphenotypic
leukemia at the age of 14 and endured 20 months of chemotherapy.
Molecular evidence for a single clonal origin in biphenotypic
concomitant chronic lymphocytic leukemia and multiple myeloma.
One MLL(+) patient expressed myeloid antigens CD33 and cyCD13 without fulfilling the criteria for biphenotypic
No undifferentiated or biphenotypic
acute leukemias were investigated in this study.