biphasic insulin


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bi·pha·sic in·su·lin

the specific antidiabetic principle of the pancreas of the ox in a solution of that from the pancreas of the pig.

biphasic insulin

An insulin formulation consisting of a mixture of intermediate- and short-acting insulin.

biphasic insulin

Endocrinology An insulin formulation consisting of a mixture of intermediate- and fast-acting insulin. See Diabetes mellitus, Insulin.

biphasic insulin

An insulin preparation that includes two components, typically a rapidly acting insulin, e.g., regular insulin, and an insulin that has a longer duration of action, e.g., NPH insulin.
See also: insulin
References in periodicals archive ?
Efficacy and Safety Analysis of Insulin Degludec/Insulin Aspart (IDegAsp) Compared with Biphasic Insulin Aspart 30 : A Phase 3, Multicenter, International, Open-label, Randomized, Treat-to-target Trial in Patients with Type 2 Diabetes Fasting during Ramadan.
Exposure to the twice-daily biphasic insulin regimen, adjusted for other variables including total insulin exposure, was associated with a 0.
Within-patient variation of the pharmacokinetics of subcutaneously injected biphasic insulin aspart as assessed by compartmental modeling, Diabetologia, 49(9): 2030-2038,
Patients previously treated with basal insulin experienced relatively greater A1C reductions with basal-bolus insulin than with biphasic insulin (1.
The mean recovery of compounds was consistent, being 101 per cent for regular insulin and 82 per cent for regular insulin in biphasic insulin.
Long-term cost effectiveness of biphasic insulin aspart 30/70 versus insulin glargine in insulin naive patients with type 2 diabetes poorly controlled on oral hypoglycemin agents in Danish, Dutch, Finnish, French, German, Norwegian, Spanish, Swedish and UK settings.
The only products that address both basal and postprandial insulin deficiencies are premixed insulins, such as NPH and regular human insulin premix (Humulin or Novolin 70/30), or the biphasic insulin analog formulations [biphasic insulin lispro (Humalog Mix 75/25) and biphasic insulin aspart (Novolog Mix 70/30)].
A dual-action insulin co-formulation such as insulin I Deg Asp) scores over biphasic insulin analogues and human insulins in achieving fasting euglycaemia, without causing nocturnal hypoglycaemia.
Using continious glucose monitoring to measure the frequency of low glucose values when using biphasic insulin aspart 30 compared with biphasic human insulin 30.
Patients were randomized to biphasic insulin aspart twice daily, prandial insulin aspart 3 limes daily, or basal insulin detemir once or twice daily.
The insulin users were further subdivided into users of glargine, long-acting human insulin, biphasic analogue, or human biphasic insulin.
The researchers focussed on the safety and effectiveness of using the biphasic insulin, which contains both fast-acting and intermediate components, prescribed by family doctors and hospital consultants.