biotin deficiency


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biotin deficiency

A rare constellation of clinical findings due to a lack of biotin, which is characterised by anaemia, dry skin, enteritis and hypercholesterolemia. Biotin deficiency is rare, as biotin is formed by intestinal flora; it occurs in those who consume raw eggs. It is a coenzyme in carboxylation reactions.
 
Sources
Egg yolks, milk, tomatoes, yeast.
 
Pathogenesis
Excess consumption of raw egg whites, which are rich in avidin, an egg-white protein that chelates biotin.

biotin deficiency

Clinical nutrition A condition caused by a lack of biotin characterized by anemia, dry skin, enteritis, and hypercholesterolemia; BD is rare, as biotin is formed by intestinal flora; it occurs in those who consume raw eggs.
References in periodicals archive ?
Biotin deficiency is almost unheard of because the vitamin is found in so many foods.
Meanwhile, Mock does not recommend that pregnant women take biotin supplements on their own, because neither the link between biotin deficiency and certain birth defects, nor a safe level of biotin supplement, are clear yet.
Is there a genetic basis for severe biotin deficiency in pregnancy?
Mock stresses that the researchers at UAMS only induce mild biotin deficiency in volunteers in order to devise a reliable laboratory test for the deficiency.
The link between biotin deficiency and birth defects in animal subjects does not prove a link in humans, so Mock is collecting blood samples from newborn babies with defects at UAMS to determine their biotin status at birth.
Mock also has determined that mild biotin deficiency occurs in at least one third of normal human pregnancies.
Now a professor of biochemistry, molecular biology and pediatrics in the UAMS College of Medicine, Mock has confirmed and extended research findings in Japan that mild biotin deficiency causes defects in the roof of the mouth and shortened limbs in animals.
Biotin deficiency in an infant fed with amino acid formula and hypoallergenic rice.
Biotin deficiency is associated with the following symptoms: dry scaly dermatitis, alopecia (hair loss), seizures, lactic acidosis and muscle pain.
A biotin deficiency causes hair to become dry and brittle, which could contribute to hair loss or thinning hair.
People with biotin deficiency may find their hair is dull because it prevents the sebaceous glands working efficiently.
The theory of biotin as a hair supplement stems from the fact that biotin deficiency manifests as thinning of the hair and loss of hair color.