biotin deficiency


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biotin deficiency

A rare constellation of clinical findings due to a lack of biotin, which is characterised by anaemia, dry skin, enteritis and hypercholesterolemia. Biotin deficiency is rare, as biotin is formed by intestinal flora; it occurs in those who consume raw eggs. It is a coenzyme in carboxylation reactions.
 
Sources
Egg yolks, milk, tomatoes, yeast.
 
Pathogenesis
Excess consumption of raw egg whites, which are rich in avidin, an egg-white protein that chelates biotin.

biotin deficiency

Clinical nutrition A condition caused by a lack of biotin characterized by anemia, dry skin, enteritis, and hypercholesterolemia; BD is rare, as biotin is formed by intestinal flora; it occurs in those who consume raw eggs.
References in periodicals archive ?
Biotin deficiency may be evidenced by rashes, dry skin, seborrheic dermatitis, brittle nails, fine or brittle hair, and hair loss.
Biotin deficiency can lead to neurological disease and affect the growth of hair and skin cells.
Biotin deficiency is almost unheard of because the vitamin is found in so many foods.
Known biotin deficiency symptoms include body hair loss and thinning, dermatitis, dry skin, and brittle finger nails," Faustino says.
Biotin deficiency in an infant fed with amino acid formula and hypoallergenic rice.
Clinical biotin deficiency (egg white injury); report of a case with some remarks on serum cholesterol.
Proposed theories for the cause of NAE describe alterations in some metabolic factor, many of which are seen in other necrolytic erythemas, including necrolytic migratory erythema, pellagra, essential fatty acid and biotin deficiency, and acrodermatitis enteropathica.
Valproate can cause biotin deficiency and may lead to low serum and liver tissue biotinidase enzyme (4); a major clinical manifestation of biotin deficiency is alopecia.
A biotin deficiency causes hair to become dry and brittle, which could contribute to hair loss or thinning hair.
Symptoms of biotin deficiency include skin, eye, and foot problems.
People with biotin deficiency may find their hair is dull because it prevents the sebaceous glands working efficiently.