biosafety level

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Related to biosafety level 4: biosafety level 2

biosafety level

(1) The degree of caution required when working with specific groups of pathogens
(2) A specific combination of work practices, safety equipment, and facilities, intended to minimise exposure of workers and environment to certain classes of pathogens.

Biosafety level 
BL 1—Organisms are relatively innocuous and are not known to cause infection in healthy human adult—e.g., Bacillus subtilis and Naegleria gruberi.
 
BL 21—Organisms are “moderate risk” agents that may cause human disease of varying severity, potentially affecting healthy adults; often good microbiologic technique, such as minimising exposure to aerosols, is a sufficient precaution for these agents—e.g., C difficile, hepatitis A, B and C, influenza A, Lyme disease, dengue fever, Salmonella; mumps, measles, HIV, scrapie, MRSA and VRSA. 

BL 32—Organisms are indigenous or exotic and may infect personnel by aerosols, autoinoculation or ingestion, resulting in potentially serious or lethal consequences—e.g., Mycobacterium tuberculosis, Bacillus anthracis, West Nile virus, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus, Hendra virus, SARS coronavirus, Salmonella typhi, Coxiella burnetii, Rift Valley fever virus, Rickettsia rickettsii and yellow fever virus.
 
BL 4—Organisms are dangerous and exotic, require a maximum containment facility and pose a high individual risk of exposure and risk to laboratory personnel—e.g., Bolivian and Argentine hemorrhagic fevers, Marburg virus, Ebola virus, Lassa fever, Crimean-Congo hemorrhagic fever and other various hemorrhagic diseases. BSL 4 agents may be transmitted by aerosol; there is no vaccine or therapy.

biosafety level

Epidemiology A classification for the degree of caution required when working with specific groups of pathogens. See Maximum containment facility.

biosafety level

(bī″ō-sāf′tē),

BSL

A classification system to indicate the safety precautions required when investigating microorganisms, esp. viruses known to be dangerous or lethal to those exposed to them. There are four BSLs, with BSL-4 requiring the highest level of security.
References in periodicals archive ?
Biosafety Level 4 is used for the diagnosis of exotic agents that pose a high risk of life-threatening disease, which may be transmitted by the aerosol route and for which there is no vaccine or therapy.
The threat of terrorists using as weapons the most deadly pathogens known, coupled with the recognition that virtually every year a new infectious disease is discovered, has led the US government to expand the number of Biosafety Level 4 (BSL-4) laboratories, also known as maximum containment laboratories (MCLs), to perform work essential for promoting public health and to ensure bioterrorism preparedness.
Bioterrorism agents used can be categorized as biosafety level 2 pathogens such as salmonella, biosafety level 3 pathogens such as Venezuelan equine encephalitis, or biosafety level 4 pathogens such as smallpox (see Table 2).
The research will be conducted with cooperation from the French research institutions CIRI (joint research unit founded by INSERM, ENS de LYON, CNRS and UCBL) and the Jean Merieux Biosafety Level 4 Laboratory in Lyon.
April 22, 2014 /PRNewswire-USNewswire/ -- Researchers from Southern Research Institute and their colleagues at Galveston National Laboratory announced today that they have jointly developed a semi-automated high-throughput screening (HTS) platform that is capable of testing 10,000 compounds per day within biosafety level 4 (BSL-4) biocontainment conditions.
In November 2003, the University of Texas Medical Branch celebrated the completion of a biosafety level 4 laboratory, the first in the United States at an academic institution.
5 million Biosafety Level 4 laboratory (BSL-4) at the University of Texas Medical Branch in Galveston, Texas.
BOSTON, April 15, 2014 /PRNewswire-USNewswire/ -- Boston City Council Committee on Government Operations, chaired by Councilors Michael Flaherty & Tito Jackson, to conduct April 16 hearing on Docket #0227, An Ordinance Regarding the Prohibition of Research Designated as Biosafety Level 4, Sponsored by Councilors Charles Yancey, Tito Jackson & Ayanna Pressley.
Culture of B virus requires a special containment facility since the virus is a biosafety level 4 pathogen (31).
Biosafety Level 4 labs are the highest-containment laboratories in existence, and the new Level 4 lab at the Emerging Infectious Disease Laboratory will double the CDC's existing Level 4 capacity.
Projection of the facility is made as an Animal Biosafety Level 4, the most dangerous possible, and Biosafety Level 3-ag, an intermediate level, for the study of foreign animal and zoonotic diseases.
New two-year study will focus on development of novel, recombinant-based diagnostic tests for two important biosafety level 4 viruses