biosafety level

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biosafety level

(1) The degree of caution required when working with specific groups of pathogens
(2) A specific combination of work practices, safety equipment, and facilities, intended to minimise exposure of workers and environment to certain classes of pathogens.

Biosafety level 
BL 1—Organisms are relatively innocuous and are not known to cause infection in healthy human adult—e.g., Bacillus subtilis and Naegleria gruberi.
 
BL 21—Organisms are “moderate risk” agents that may cause human disease of varying severity, potentially affecting healthy adults; often good microbiologic technique, such as minimising exposure to aerosols, is a sufficient precaution for these agents—e.g., C difficile, hepatitis A, B and C, influenza A, Lyme disease, dengue fever, Salmonella; mumps, measles, HIV, scrapie, MRSA and VRSA. 

BL 32—Organisms are indigenous or exotic and may infect personnel by aerosols, autoinoculation or ingestion, resulting in potentially serious or lethal consequences—e.g., Mycobacterium tuberculosis, Bacillus anthracis, West Nile virus, Venezuelan equine encephalitis virus, Eastern equine encephalitis virus, Hendra virus, SARS coronavirus, Salmonella typhi, Coxiella burnetii, Rift Valley fever virus, Rickettsia rickettsii and yellow fever virus.
 
BL 4—Organisms are dangerous and exotic, require a maximum containment facility and pose a high individual risk of exposure and risk to laboratory personnel—e.g., Bolivian and Argentine hemorrhagic fevers, Marburg virus, Ebola virus, Lassa fever, Crimean-Congo hemorrhagic fever and other various hemorrhagic diseases. BSL 4 agents may be transmitted by aerosol; there is no vaccine or therapy.

biosafety level

Epidemiology A classification for the degree of caution required when working with specific groups of pathogens. See Maximum containment facility.

biosafety level

(bī″ō-sāf′tē),

BSL

A classification system to indicate the safety precautions required when investigating microorganisms, esp. viruses known to be dangerous or lethal to those exposed to them. There are four BSLs, with BSL-4 requiring the highest level of security.
References in periodicals archive ?
Biosafety Level 3 applies to agents that may be transmitted by the respiratory route and can cause serious infection.
Bioterrorism agents used can be categorized as biosafety level 2 pathogens such as salmonella, biosafety level 3 pathogens such as Venezuelan equine encephalitis, or biosafety level 4 pathogens such as smallpox (see Table 2).
This volume, published in March 1995, stated that all microbiology laboratories providing service at the American Thoracic Society Level II or Level III had to provide Biosafety Level 3 protection.
biosafety Level 3 containment facility to be built on the U of S campus by 2009.
All laboratory procedures and animal studies were conducted in biosafety level 3 agriculture (BSL-3AG) (15) facility with HEPA respiratory protection and barrier clothing procedures for personnel.
The Company will use a portion of the new money to enhance its bio-defense capabilities by expanding, upgrading and equipping its accredited biosafety level 3 laboratory suite.
announced today its Biodefense Laboratory has been certified for Biosafety Level 3 operations under Center for Disease Control/National Institute of Health (CDC/NIH) requirements.
The high case-fatality ratio of HCPS (40%), coupled with its airborne transmission by captive rodents, has led to classification of the agents of HCPS as biosafety level 3 (BSL-3) in tissue culture and BSL-4 in reservoir host rodents.
In fact, we are expanding our biosafety level 3 facility to accommodate certain aspects the new work.
Although no research involving live SARS viruses was known to have taken place in this laboratory, SARS coronavirus that had been inactivated in a Biosafety Level 3 laboratory in the Institute was used on several occasions during the early months of 2004 in experiments carried out in this area.
The Company is seeking additional equity financing to enhance its bio-defense capabilities with regard to expanding and upgrading its accredited biosafety level 3 laboratory suite.
In these guidelines, WHO strongly recommends Biosafety Level 3 (BSL 3) as the minimum containment level to work with live SARS coronavirus.