bioluminescence imaging


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bioluminescence imaging

A noninvasive imaging modality which is widely used in pre-clinical oncology research in a range of activities—e.g., imaging animal tumour models by luciferase-expressing cells after administering a substrate, drug development, gene monitoring, evaluating tumour development, metastasis and protein interactions.
References in periodicals archive ?
Researchers at Caltech and CHLA created a mouse model of Ewing's sarcoma that mimics the tumor localizations in humans and also provides for simultaneous, real time bioluminescence imaging of the disseminated tumors by using human Ewing's sarcoma cells engineered to express luciferase.
In animal models using sensitive bioluminescence imaging, treatment with HuMax-CD38 slowed tumor growth in both preventive and therapeutic settings in SCID mice.
In the technique, dubbed "cell-specific in vitro bioluminescence imaging," or CS-BLI, the cancer cells in each sample are equipped with a gene that makes them glow - a process unaffected by the normal cells nearby.
While we generally respect the contributions of Caliper/Xenogen to the field of bioluminescence imaging, we believe it is clear, and also fundamentally understood in the industry, that that the basic methods of fluorescence in vivo imaging were well known and in use before the priority date of the '851 patent, and therefore that the claims therein are clearly invalid.
Xenogen scientists as well as other researchers have previously demonstrated the value of non-invasive in vivo bioluminescence imaging for drug development, using a wide variety of other tumor model systems.
The study evaluated KOS-953 in a mouse model of diffuse multiple myeloma bone lesions and utilized whole-body fluorescence and bioluminescence imaging to follow the treated mice.