biologically effective dose

bi·o·log·ic·al·ly ef·fec·tive dose

(BED) (bī'ō-loj'ik-ă-lē e-fek'tiv dōs)
The amount of an absorbed compound that reaches targets or sites of action within the body to cause a biologic effect.
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References in periodicals archive ?
T] itself (compared with either integrated exposure or internal dose) will better predict response because even large short-term fluctuations in exposure will not directly provide important information on biologically effective dose.
Dacogen was given initially as a single agent to identify the biologically effective dose (i.
The first is a phase II clinical trial involving the study of SABR's role in the treatment of large, early stage non-small cell lung cancer, involving, according to Chi, the delivery of a higher than conventionally accepted Biologically Effective Dose, or BED.
20] It is not surprising that LDR brachytherapy (which provides a biologically effective dose of 101 Gy) improves the seven-year biochemical disease-free survival (bDFS) compared to 68 Gy (94% vs.
They reviewed the literature to determine whether levels of oxidatively damaged DNA and lipid peroxidation products in cells or bodily fluids from humans might be useful biomarkers of biologically effective dose in studies on the health effects of exposure to PM.
This aflatoxin-DNA adduct excretion product serves as a biomarker of the biologically effective dose of aflatoxin, and elevated levels are associated with increased risk of liver cancer.
In addition, the younger men were more likely to receive a full biologically effective dose of radiation: 92% vs.
Utilising the concept of the biologically effective dose to define the particle and fibre hazards of carbon nanotubes
Investigating the safety and efficacy of metronomic dosing, frequent oral administration at a comparatively low, but biologically effective dose, is of particular interest.
They also proposed four categories of biomarkers: internal dose, biologically effective dose, early biologic response, and susceptibility.
Patients who received the higher biologically effective dose (30 Gy) or higher of preoperative radiation had the lower rate of recurrences (Lancet 358[9290]:1291-1304, 2001).
In the initial stage, patients will receive escalating doses of SGI-110 until the maximum tolerated dose (MTD) or the biologically effective dose (BED) is determined.

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