biological plausibility

biological plausibility

a method of reasoning used to establish a cause-and-effect relationship between a biological factor and a particular disease.

biological plausibility

A term referring to the results of research or a trial which are believable in terms of current scientific biological knowledge.
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The CHMP's position is that betrixaban efficacy is acknowledged in the APEX trial, but uncertainties remain regarding a positive benefit risk, which is not supported by a second confirmatory study, biological plausibility for betrixaban in another approved indication or external support within the class from other Factor Xa inhibitors, which are not approved for the acute medically ill population.
our study helps strengthen the biological plausibility of the link between traffic-related air pollution and cardiovascular disease.
It is hard to see the biological plausibility of a method of induction affecting meaningful obstetric variables (such as the size of the fetus, the position and station of the presenting part, or the dimensions of the maternal pelvis once active labor is established).
Lead scientist Dr Griffith Bell, from the University of Washington School of Public Health in Seattle, said: "Our study helps strengthen the biological plausibility of the link between trafficrelated air pollution and cardiovascular disease.
Lead scientist Dr Griffith Bell, from the University of Washington School of Public Health in Seattle, US, said: "Our study helps strengthen the biological plausibility of the link between traffic-related air pollution and cardiovascular disease.
By anchoring exposures to specific biological alterations, the exposome can link exposures to health outcomes and also provide guidance into testing the biological plausibility of exposures in laboratory models.
Whilst the mechanistic evidence is limited, there is a biological plausibility for the association between hot beverages and cell injury and the potential for sequelae that may lead to cancerous changes.
Existing approaches to the study of the neural mechanisms of time mainly focus on the identification of brain regions involved in temporal computations (where time is processed in the brain), whereas most computational models vary in their biological plausibility and do not always make clear testable predictions.
These results are consistent with the biological plausibility that the mechanism of action relates to the effect of methylphenidate on the heart rate," the authors concluded.
1016/S1473-3099[16]00095-5), does not prove that Zika virus infection causes micro-cephaly but does suggest the biological plausibility of such a link.
So when is biological plausibility enough to support a change in practice?
But they added: "The well-known association of sweetened beverages with obesity and type 2 diabetes, which are risk factors for heart failure, reinforces the biological plausibility of (the) findings.