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biological half-life |
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half-life (haf´līf) the time required for the decay of half of a sample of particles of a radionuclide or elementary particles; symbol t 1/2 or T 1/2. antibody half-life a measure of the mean survival time of antibody molecules following their formation, usually expressed as the time required to eliminate 50 per cent of a known quantity of immunoglobulin from the animal body. Half-life varies from one immunoglobulin class to another. biological half-life the time required for a living tissue, organ, or organism to eliminate one-half of a radioactive substance which has been introduced into it.
biological half-life T1/2 Biology The time required for 1⁄2 of the total amount of a particular substance in a biologic system to be degraded by biological processes when the rate of removal is nearly exponential Radiation
physics The length of time required for1/2 of a radioactive substance to be biologically eliminated from the body How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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This technology is designed to improve the stability, biological half-life and immunologic characteristics of therapeutic proteins naturally. One of the earliest toxicokinetics studies reported that Pb, once absorbed into the blood compartment, has a mean biological half-life of about 40 days in adult males (Rabinowitz et al. by pulmonary delivery, and to predictably extend the biological half-life of SCAs by PEGylation, further expands the clinical utility of SCA products beyond the range of monoclonal antibodies. |
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