Indeed, she has been doing that all along in selected cases on the basis of clinical judgment and biologic plausibility
while anxiously awaiting the IMPROVE-IT findings, which come as a great relief, she added.
In addition, the exposure metric raises issues regarding the biologic plausibility
of benzene as the underlying causal agent for the observed effects.
It leaves little doubt that these observational data are biologic plausibility
The higher rate of preterm birth prior to 32 weeks of gestation among those with inadequate weight gain was attributable to spontaneous preterm birth, as there was no difference in the rates of indicated preterm birth among those with and without adequate weight gain, she explained, noting that "the biologic plausibility
of the effect of gestational weight gain on the rate of spontaneous preterm birth is unknown.
If the threshold of expected occurrence is not exceeded but there appears to be an argument for biologic plausibility
or much public health interest, investigators must use their best judgment when deciding if further investigation is warranted.
Evidence from animal or mechanistic studies sometimes adds support to the epidemiologic evidence or suggests biologic plausibility
when human evidence is lacking for a particular factor.
The biologic plausibility
of a link between ADHD symptoms and obesity is based on results from positron emission tomography studies showing a reduced availability of dopamine receptors in people with ADHD and in people who are obese.
This work is a comprehensive review of this literature and a summary of the principal epidemiologic criteria supporting asbestos as a cause of laryngeal cancer, namely: (1) consistency of the epidemiologic studies, (2) biologic plausibility
, (3) strength of association, (4) dose-response effect, and (5) effect modification.
For those with a more evidence-based approach, Jain's contributors are at times too ready to accept biologic plausibility
and anecdote as a justification for routine practice.
While many different formal systems are available for determining causality from case reports, most systems rely on five basic data elements: 1) the timing of the adverse event relative to ingestion of the drug (or herb); 2) the presence of other factors that might have caused the event; 3) the result of withdrawing the drug ("de-challenge"); 4) the result of reintroducing the drug ("re-challenge"); and 5) other supporting evidence, including similar cases and biologic plausibility
The biologic plausibility
of any assumed benefits of HAART should be considered.
In some cases, the association with weather is supported, but the biologic plausibility