biologic activity

biologic activity,

the inherent capacity of a substance, such as a drug or toxin, to alter one or more chemical or physiologic functions of a cell, tissue, organ, or organism. The biologic activity of a substance is determined not only by the substance's physical and chemical nature but also by its concentration and the duration of cellular exposure to it. Biologic activity may reflect a "domino effect," in which the alteration of one function disrupts the normal activity of one or more other functions.
References in periodicals archive ?
Cellectar's research programs have generated numerous PDC molecules that in preclinical studies show significant improvement in pharmacologic and biologic activity versus the parent or payload molecule alone.
The company's proprietary CryoTek preservation method ensures the tissue retains its biologic activity and healing components.
Given its wide range of biologic activity, and some promising cutaneous results, there is reason to believe that ursolic acid has the potential to play an increasingly useful role in topical skin care agents and dermatologic practice.
Following transplantation, the patients will be monitored for 12 months to evaluate the safety and biologic activity of ISC-hpNSC.
This study was able to examine the presence and biologic activity of a much greater number of them in sealcoats than has been done in any previous research.
Approximately 90 billion tons come from biologic activity in Earth's oceans and another 90 billion tons from such sources as volcanoes and decaying land plants.
The resulting enhanced biologic activity promotes rapid healing via tissue regeneration for patients requiring bone-grafting procedures.
LJPC-30Sa and LJPC-30Sb retain the biologic activity of gentamicin, yet appear to lack the traditional kidney toxicity associated with it.
But codeine, the molecule itself, has no biologic activity or drug effect on its own.
The two studies provide the first evidence of the mid- to long-term safety, survival, and potential biologic activity of pluripotent stem cell progeny into humans with any disease.
BAY 94-9027 has been designed to extend the circulating half-life of rFVIII activity through site specific attachment of a polyethylene glycol (PEG) polymer to the light chain of the rFVIII molecule, while preserving its full biologic activity.
It's also possible that some unknown biologic activity could be at play.