bioelectronic chip

bioelectronic chip

A minitiarised diagnostic device for biomarker detection, which combines microfluidics and electronics, separating the material from the cells with an electric charge.
References in periodicals archive ?
Isolation of cultured cervical carcinoma cells mixed with peripheral blood cells on a bioelectronic chip.
6,989,086, "Channel-less Separation of Bioparticles on a Bioelectronic Chip by Dielectrophoresis" by the U.
San Diego, CA), developer of advanced diagnostic products, announced that it was issued United States Patent 6,864,071, "Multiplex amplification and separation of nucleic acid sequences using ligation-dependent strand displacement amplification and bioelectronic chip technology," by the United States Patent and Trademark Office.
CMS's bioelectronic chip measures a different type of nucleic acid characteristic than traditional diagnostic testing methods such as absorbance photometry, turbidimetry, fluorescence polarisation or Ion Selective Electrode (ISE) potentiometry.
6,280,590, "Channel-Less Separation of Bioparticles on a Bioelectronic Chip by Dielectrophoresis"; and U.
6,238,868 (the "'868 patent"), is entitled "Multiplex Amplification And Separation Of Nucleic Acid Sequences Using Ligation-Dependent Strand Displacement Amplification and Bioelectronic Chip Technology.
The '868 patent claims cover a kit and methods employing ligation-dependent strand displacement amplification ("SDA") on a bioelectronic chip that facilitate optimization of multiplex amplification, detection and analysis of nucleic acid sequences.
6,071,394 entitled "Channel-Less Separation of Bioparticles On A Bioelectronic Chip By Dielectrophoresis" are the sixteenth and seventeenth U.
The scope of analytical microchips spans microfluidic chips that allow control of microliter volumes of fluid, bioelectronic chips that incorporate both microfluidic and electronic control or detection components, and microarray chips formed from dense arrays of protein or nucleic acid reagents.
Bioelectronic chips are illustrated by a chip with interdigitated electrodes for impedimetric detection of DNA, chips that incorporate acoustic shear wave sensors for studying interaction of HIV-1 mRNA with peptides, and an electrochemical enzyme immunoassay chip that uses capillary electrophoresis--based separation of bound and free fractions followed by electrochemical detection of the alkaline phosphatase label.