Although prediction includes a variety of outcome measures, in these models, ischemia is distinguished from controls by measuring biochemical markers
involved in the ischemic cascade.
Instead, the clear message from this and several other sources is that biochemical markers
of bone turnover/remodeling are very effective tools for monitoring the effectiveness of antiresorptive therapy in individual patients as well as in groups of patients.
Type I collagen is degraded during the bone resorption process, liberating small fragments, such as NTX, ([beta]-CTX, PYD, and DPD, into the blood and then into the urine (5, 31) and making serum and urinary concentrations of these fragments available as biochemical markers
of bone resorption.
Can today's level of biochemical markers
predict future bone density in the absence of pharmacologic intervention?
The study by Thomas and Thomas (1) convincingly demonstrates that biochemical markers
are relatively insensitive in diagnosing functional iron deficiency.
Almost all biochemical markers
decreased after 1 or 3 months of estrogen replacement.
The response profiles of the biochemical markers
of bone turnover differ with different treatment protocols.
No other publication that I know of has such a comprehensive collection of clinical and technical information available on the current and future biochemical markers
To compare the performance of the biochemical markers
, the ROC curves were estimated and the areas under these curves were calculated for every biochemical marker
For those already suffering with chronic disease, once the biochemical markers
are identified, strategies can be put in place to reverse chronic disease.
15,16 Use of biochemical markers
of bone turnover is beneficial for assessing changes in BMD during anti resorptive treatment and in population studies of osteoporosis.
The scientists used magnetic resonance metabolic profiling to analyze the biochemical markers
in the blood and urine of 61 patients with celiac disease, 29 with potential celiac disease, and 51 healthy people.