Traditionally in radical prostatectomy (RP) patients, biochemical failure
after salvage radiation is managed with androgen deprivation therapy (ADT) to slow disease progression.
From the TJU cohort (n=139), cumulative incidence of biochemical failure
post radiation therapy at 6 years post radiation therapy was 21% for low Decipher score, 40% for average Decipher score and 63% for high decipher score (p<0.
Moreover, it has been shown that biochemical failure
is not equal to clinical relapse (2).
James Jensen, Department of Surgery--"Feasibility and Safety of Nutritional Supplementation with Omega-3 Fatty Acids to Reduce Prostate Specific Antigen Rise in Men with Biochemical Failure
after Prostatectomy or External-Beam Radiotherapy"
Nor were there differences in biochemical failure
, regional or distant recurrence, pelvic metastases, or the need for a second course of androgen blockade.
Freedom from biochemical failure
was defined as a serum PSA level < or =0.
The researchers then compared the biochemical failure
rates (a statistical measure of whether the cancer relapses) and determined that men who received the proton/photon therapy had the same rate of recurrence as the men who received brachytherapy.
Presalvage prostate-specific antigen (PSA) and PSA doubling time as predictors of biochemical failure
of salvage cryotherapy in patients with locally recurrent prostate cancer after radiotherapy.
Hypoxic prostate/muscle pO2 (P/M pO2) ratio predicts for biochemical failure
in patients with localized prostate cancer: long-term result [abstract 5136].
2) What is the contribution of treatment to observed declines in prostate cancer mortality, especially the transition from the use of androgen deprivation therapy after biochemical failure
This academic study is a phase I/II study of 30 HLA A2+ patients with biochemical failure
of prostate cancer.
Session Title: "Improvement in prostate cancer biomarkers measurement" Abstract Title: "Validation of a genomic classifier for predicting biochemical failure
following post-operative radiation therapy in high-risk prostate cancer" Date and Time : Saturday, April 12, 2014, 4:00 p.