biochemical failure

biochemical failure

asymptomatic disease recurrence marked only by variance in values determined on clinical laboratory monitoring.

biochemical failure

An oncology term of art referring to an increase in PSA after what was thought to be definitive therapy for prostate cancer, which is usually an indicator of local or metastatic disease progression.
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Traditionally in radical prostatectomy (RP) patients, biochemical failure after salvage radiation is managed with androgen deprivation therapy (ADT) to slow disease progression.
From the TJU cohort (n=139), cumulative incidence of biochemical failure post radiation therapy at 6 years post radiation therapy was 21% for low Decipher score, 40% for average Decipher score and 63% for high decipher score (p<0.
Moreover, it has been shown that biochemical failure is not equal to clinical relapse (2).
James Jensen, Department of Surgery--"Feasibility and Safety of Nutritional Supplementation with Omega-3 Fatty Acids to Reduce Prostate Specific Antigen Rise in Men with Biochemical Failure after Prostatectomy or External-Beam Radiotherapy"
Nor were there differences in biochemical failure, regional or distant recurrence, pelvic metastases, or the need for a second course of androgen blockade.
The researchers then compared the biochemical failure rates (a statistical measure of whether the cancer relapses) and determined that men who received the proton/photon therapy had the same rate of recurrence as the men who received brachytherapy.
Presalvage prostate-specific antigen (PSA) and PSA doubling time as predictors of biochemical failure of salvage cryotherapy in patients with locally recurrent prostate cancer after radiotherapy.
Hypoxic prostate/muscle pO2 (P/M pO2) ratio predicts for biochemical failure in patients with localized prostate cancer: long-term result [abstract 5136].
2) What is the contribution of treatment to observed declines in prostate cancer mortality, especially the transition from the use of androgen deprivation therapy after biochemical failure (i.
This academic study is a phase I/II study of 30 HLA A2+ patients with biochemical failure of prostate cancer.
Session Title: "Improvement in prostate cancer biomarkers measurement" Abstract Title: "Validation of a genomic classifier for predicting biochemical failure following post-operative radiation therapy in high-risk prostate cancer" Date and Time : Saturday, April 12, 2014, 4:00 p.