biochemical disease-free survival


Also found in: Acronyms.

biochemical disease-free survival

The survival time of a person with a cancer (e.g., prostate cancer) during which a biochemical marker (e.g., PSA) does not rise or rises very little (e.g., < 1.0 ng/mL, or on less than 3 consecutive occasions).
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Table 2: Biochemical disease-free survival for intermediate and high risk patients treated with a combination of HDR brachytherapy and external beam radiotherapy [Table omitted]
37) (39) (38) Patients (n) 49 25 31 Follow-up (months, 64 47 30 mean) BDFS [years, n 34 (5%) 70 (4%) 87 (5%) (%)] Failure definition Phoenix Phoenix ASTRO Incontinence (%) 6 0 0 Patients with GU toxicity (%) Grade 1-2 12 NR NR Grade 3-4 14 16 NR Patients with GI toxicity (%) Grade 1-2 4 NR NR Grade 3-4 2 24 5 BDFS: biochemical disease-free survival, ASRTO: American Society for Therapeutic Radiation and Oncology, GU: genitourinary, GI: gastrointestinal, NR: not reported.
Twelve-year biochemical disease-free survival (bDFS) rates are 98% and 96% for low- and intermediate-risk disease.
After a median follow-up period of 35 months (the range was 4-77 months), the PSA biochemical disease-free survival rate was 83 percent of patients according to the American Society for Therapeutic Radiology and Oncology (ASTRO) criteria.