IL4

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IL4

A gene on chromosome 5q31.1 that encodes interleukin-4, a pleiotropic cytokine produced by activated T cells, which participates in several B-cell activation processes. IL-4 is a ligand for IL4 receptor (as is IL13), and it induces the expression of class II MHC molecules on resting B-cells. It activates several B-cell and other cell processes; is a co-stimulator of DNA-synthesis; enhances secretion and cell surface expression of IgE and IgG1; and regulates expression of the low-affinity Fc receptor for IgE (CD23) on lymphocytes and monocytes.