The regulatory machinery works when proteins called transcription factors bind to specific short sequences of DNA that flank the gene, called transcription factor binding sites
, and by doing so, switch genes on and off.
C8[alpha] contains one or more lipid binding sites
that become exposed within the MAC.
Because the actual binding sites
were visualized, he believes that the MOF can be rationally designed to work even better.
The choline ends can occupy multiple choline binding sites
of the CBP simultaneously.
Bioflavonoid interactions with rat uterine type II binding sites
and cell growth inhibition.
Genpathway's new assays enabled us to rapidly identify a number of strong binding sites
More precise identification of the binding sites
is currently being investigated by subjecting labeled peptide fragments to analysis by HPLC and mass spectrometry.
The natural enzyme is stabilized in part by the presence of bound calcium at two different sites, a high-affinity site (site A) and a weaker less specific binding site
Additionally, the company has also received a composition of matter patent allowance broadly claiming small, organic molecules that bind to DNA in a sequence-specific manner to alter gene expression by displacing transcription factors from their binding sites
Starting with a protein crystal structure, an in silico collection of 40,000 molecular fragments and one of the world's largest privately-owned Linux-based supercomputer clusters, Locus first identifies optimum ligand binding sites
and the binding affinity of molecular fragments on protein targets.
Each CV-N protein has two binding sites
where it can bind to a carbohydrate and that both sites are needed to neutralize HIV.
The researchers spaced the peptides to match the array of binding sites