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binding site

   Also found in: Dictionary/thesaurus, Legal, Financial, Encyclopedia, Wikipedia 0.01 sec.
site (sīt) a place, position, or locus.
allosteric site  a site on a multi-subunit enzyme that is not the substrate binding site but that when reversibly bound by an effector induces a conformational change in the enzyme, altering its catalytic properties.
antigen-binding site , antigen-combining site the region of the antibody molecule that binds to antigens.
binding site  in an enzyme or other protein, the three-dimensional configuration of specific groups on specific amino acids that binds specific compounds, such as substrates or effectors, with high affinity and specificity.
operator site  a site adjacent to the structural genes in the operon, where repressor molecules are bound, thereby inhibiting the transcription of the genes in the adjacent operon.
restriction site  a base sequence in a DNA segment recognized by a particular restriction endonuclease.

binding site
Etymology: ME, binden + L, situs
the location on the surface of a cell or a molecule where other cell fragments or molecules attach to initiate a chemical or physiologic action.

binding site,
n the location on the surface of a cell or molecule where other cell fragments or molecules attach to initiate a chemical or physiologic action.

Patient discussion about binding site.

Q. My friend has Progressive MS, he is bound to a wheelchair, Prognosis? How can I help? He must be moved by a Hoyer Lift, he has caregivers. He has a beautiful voice and does have enough ability to move in his chair around local community. He has some bad days with spacicity, I want to help but am unsure as to how? He is 60? or so and lives on his own, he has had MS for many years and a number of complications, such as pneumonia and decubitus. Please help me to help him!

A. There are a number of ideas and resources for social and recreational activities (i.e. wheelchair sports, dancing, travel, aviation, etc.) that may be helpful, which can be found at www.mobility-advisor.com.

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The researchers say that they have identified a binding site for alcohol in an ion channel that plays a key role in several brain functions associated with drugs of abuse and seizures.
If the EPR spectra of Cu(II)-bound H86A frataxin loses the signal for histidine coordination, this will indicate the location of one potential iron binding site.
Although this phenomenon has been initially related to multi-subunit enzyme complexes, where ligand binding at one subunit affects binding site affinity on other subunit(s) [1-3], more recently attention has been paid to the possibility of allosteric regulation within monomeric proteins [3,4].
 
 
 
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