binding domain

binding domain

Any structural motif present on a DNA-binding regulatory protein which controls gene expression, either enhancing or repressing mRNA synthesis. Binding proteins recognise sequence-specific binding domains on DNA and often share sequence homology with each other—e.g., leucine zipper motif and protein products of the myc, fos, and jun proto-oncogenes.
References in periodicals archive ?
In this context Polish provides a testing ground for our claim that LF movement does not alter the binding domain.
The domain structure of Chi-54 gene shows a cellulose binding domain (CBD), chitin binding domain (ChBD), a catalytic domain (CD), and a signal peptide (SP), (Fig 1).
The ligand binding domain consists of seven repeats, each containing six cysteine residues, which form disulphide bonds within each repeat.
The activation of EGFR may be inhibited by a number of mechanisms including antibody therapy directed against the extracellular ligand binding domain and small molecule inhibitors targeting the intracellular tyrosine kinase domain.
Molecules designed to block ATP from attaching to its binding domain will inhibit tyrosine phosphorylation and block signal transduction.
Anillin contains an actin binding domain that is necessary for the protein's direct association with actin.
Therefore, the loop region can be referred to as a "pencil binding domain," and the region(s) of the pipe cleaner held by the students (by which the protein "binds" to the hands) can be referred to as the "handle domain(s).
LEDGF contains a putatively chromatin-binding N-terminal fragment, as well as an Integrase Binding Domain (IBD) that is mapped to the C-terminal end (residues 347-429) [40,68].
This paper deals with the structure of the molecular interaction as studied by X-ray crystallography and fluorescence anisotropy, of the RXR binding domain with a rexinoid agonist (CD3254, see below, and its analogues).
determined the crystal structure of the ligand binding domain of a vascular