Effect of pravastatin, an HMG CoA reductase inhibitor, and cholestyramine, a bile acid sequestrant
, on lipoprotein particles defined by their apolipoprotein composition.
9,23) Bile acid sequestrants
would be the second choice for treatment of patients with isolated elevated cholesterol.
WelChol is the top-selling branded drug in the bile acid sequestrants
Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds (HMG-CoA reductase inhibitors, bile acid sequestrants
(resins), fibric acid derivatives, and plant stanols).
WelChol, a non-absorbed specifically engineered bile acid sequestrant
(SE-BAS) indicated for LDL-C lowering approved by the U.
Combining a bile acid sequestrant
to provide additional LDL-cholesterol-lowering with a fenofibrate to lower triglyceride levels may provide an alternate therapy which can positively affect lipid levels.
The findings were consistent across two different dosing options of the two cholesterol-lowering therapies -- when WelChol, a bile acid sequestrant
(BAS), was given at the same time as TriCor, a fibrate, or when TriCor was given four hours prior to WelChol.
Other major lipid-modulating drugs, such as Zetia (ezetimibe), the fibrates, bile acid sequestrants
, omega-3 fish oil agents, and rare-disease therapies comprise the remainder of the current dyslipidemia space.
To calculate the market size, the Global Type 2 Diabetes Therapeutics Market 2015-2019 report considers revenue generated through the sales of drugs like DPP-4 inhibitors, Biguanides, Insulins, GLP-1 receptor agonists, Thiazolidenediones, Sulfonulureas, SGLT-2 inhibitors, a-Glucosidase inhibitors and others (amylinomimetics, bile acid sequestrants
, and dopamine receptor agonists).
Certain medications, including estrogens, bile acid sequestrants
, and protease inhibitors, can raise triglyceride levels.
They are largely derived from wood pulp and decrease the absorption of cholesterol across the gut wall by a mechanism separate from ezetimibe or the bile acid sequestrants
The therapy chapters include discussion of such topics as treatment guidelines, exercise and lipids, weight loss, statins, bile acid sequestrants
, cholesterol absorption inhibitors, nicotinic acid, fibrates, endocannabinoid receptor blockers, modulation of biomarkers of inflammation, invasive imaging modalities and atherosclerosis, and noninvasive imaging modalities.