bile acid


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Related to bile acid: bile salt

bile acid

/bile ac·id/ (bīl as´id) any of the steroid acids derived from cholesterol; classified as primary, those synthesized in the liver, e.g., cholic and chenodeoxycholic acids, or secondary, those produced from primary bile acids by intestinal bacteria, e.g., deoxycholic and lithocholic acids. Most of the the bile acids are reabsorbed and returned to the liver via the enterohepatic circulation. Cf. bile salt under salt.

bile acid

n.
Any of the liver-generated steroid acids, such as cholic acid, that commonly occur in the bile in combination with glycine and taurine as sodium salts.

bile acid

a steroid acid of the bile, produced during the metabolism of cholesterol. On hydrolysis, bile acid yields glycine and choleic acid.

bile acid

Either of several acids—e.g., cholic acid (CA), chenodeoxycholic acid (CDA)—which are formed in the liver and converted by intestinal bacteria into deoxycholic acid (from CA) and lithocholic acid (from CDA), which are known as secondary BAs. BAs are conjugated in the liver to glycine or taurinese conjugates; glycocholic acid and taurocholic acid form sodium and potassium salts in the alkaline bile in the liver. These conjugated bile acids have a central role in the emulsification and absorption of fatty acids.

Specimen
Serum.
 
Ref range
< 60 µg/mL—as cholylglycine.
 
Method
RIA.
References in periodicals archive ?
Dietary TCDF induced alterations in the gut microbiota accompanied by modulation of bile acid metabolism and host immune responses.
with chronic cholestasis (accumulation of bile acids in the liver) and
22) Conjugated bile acids are more water- soluble than free bile acids, meaning they are better able to assist with the absorption of cholesterol.
Bioassays of total cholesterol and bile acids in the feces
In addition, levels of serum bile acids, which are another biomarker of cholestasis, and levels of liver triglycerides, an indicator of steatosis, were nearly normal in the CDCA-treated TPN piglets.
Dilution protocol of bile acids in Lowenstein-Jensen medium Lowenstein-Jensen medium with bile acid additives Lithocolic acid Cholic acid (mg/ml) (mg/ml) Dilution 1 2 32 Dilution 2 1 16 Dilution 3 0.
Although we found that LCA greatly extends yeast longevity, yeast do not synthesize this or any other bile acid found in mammals," says senior author Vladimir Titorenko, Concordia University Research Chair in genomics, cell biology and aging and a professor in the Department of Biology.
Serum concentrations of 7[alpha]-hydroxycholest4-en-3-one (cholesten, bile acid synthesis intermediate) have been shown to correlate with the severity of bile acid malabsorption (1, 2).
SAN FRANCISCO -- Check serum bile acid levels to determine if severe itching during pregnancy is the result of intrahepatic cholestasis of pregnancy, advises a dermatologic pathologist.
Lastly, a marked increase in LCAT activity in the colesevelam HCl-treated rabbits further supports the conclusion that inhibiting bile acid reabsorption and depleting hepatic bile acid stores results in stimulation of reverse cholesterol transport.
The research on bile acid binding showed only slight activity for Burcon's proteins, which was not statistically different than that of soy protein isolate.